Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-701-7 | CAS number: 2871-01-4
Endpoint summary
Administrative data
Description of key information
According to the available studies (Reed, 1984, Klimisch 2, Human Repeated Insult Patch Test) performed in order to assess the potential sensitising effect of the test substance, HC Red did not led to sensitization when used at 3%.
Additional information
Two keys studies were available to assess the potential sensitising effect of the test substance : Two Human Repeated Insult Patch Tests were performed (Reed, 1983 & 1984, Klimisch 2)
The entire study extended over a six weeks period with three phases: induction, rest and challenge. The induction phase consisted of 10 consecutive applications of the test material. The patches were removed 48 hours after application and skin was evaluated. The challenge phase was initiated during the sixth week of the study, with identical patches applied to sites on the opposite arm previously unexposed to the test material. Patches were removed after 48 hours. The sites were grades 48 and 72 hours after removal.
- None of the 114 subjects used in the first study developed sensitization due to treatment with the test item (concentration was not reported).
- None of the 115 subjects used in the second study developed sensitization due to treatment with the 3% test item
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
