5-(dithiolan-3-yl)valeric acid

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2016-10-10

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2016

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

GLP compliance:

yes

Other quality assurance:

ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Test material

Test material information

Constituent 1

Reference substance name:

5-(dithiolan-3-yl)valeric acid

EC Number:

214-071-2

EC Name:

5-(dithiolan-3-yl)valeric acid

Cas Number:

1077-28-7

Molecular formula:

C8H14O2S2

IUPAC Name:

5-(1,2-dithiolan-3-yl)pentanoic acid

impurity 1

Reference substance name:

unknown

IUPAC Name:

unknown

impurity 2

Reference substance name:

Water

EC Number:

231-791-2

EC Name:

Water

Cas Number:

7732-18-5

Molecular formula:

H2O

IUPAC Name:

dihydrogen oxide

Test material form:

solid: bulk

Details on test material:

This composition is the usual techical grade of AlzChem AG. It will be used when test substance has this composition (or is very closed) or no specific information is available

Results and discussion

Particle size

Particle size 1

Key result

Percentile:

D10

Mean:

<= 34.63 µm

Remarks on result:

other: SD not determined

Particle size 2

Key result

Percentile:

D50

Mean:

<= 81.5 µm

Remarks on result:

other: SD not determined

Particle size 3

Key result

Percentile:

D90

Mean:

<= 194 µm

Remarks on result:

other: SD not determined

Particle size 4

Key result

Percentile:

D95

Mean:

<= 174.31 µm

Remarks on result:

other: SD not determined

Particle size 5

Key result

Percentile:

other: D98

Mean:

<= 205.2 µm

Remarks on result:

other: SD not determined

Particle size 6

Key result

Percentile:

other: D100

Mean:

<= 610 µm

Remarks on result:

other: SD not determined

Particle size distribution at different passages

No.:

#1

Remarks on result:

not measured/tested

Any other information on results incl. tables

Parameter	Result	Method
10 % of the sample Particle size	≤ 34.63 µm	Laser Difffraction
50 % of the sample Particle size	≤ 81.50 µm	Laser Difffraction
90 % of the sample Particle size	≤ 149.00 µm	Laser Difffraction
95 % of the sample Particle size	≤ 174.31 µm	Laser Difffraction
98 % of the sample Particle size	≤ 205.20 µm	Laser Difffraction
100 % of the sample Particle size	≤ 610.00 µm	Laser Difffraction
SMD	≤ 49.78 µm	Calculated
VMD	≤ 89.06 µm	Calculated
SV	≤ 0.12 m^2/cm^3	Calculated

Applicant's summary and conclusion

Conclusions:

Alpha Lipoic Acid has a SMD of 49.78 µm (Calculated)
Alpha Lipoic Acid has a VMD of 89.06 µm (Calculated)

Executive summary:

Alpha Lipoic Acid has a SMD of 49.78 µm (Calculated)  Alpha Lipoic Acid has a VMD of 89.06 µm (Calculated)