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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Remarks:
The test substance (Citronellal; CAS 106-23-0) represents the racemate of the registered substance (R)-3,7-dimethyloct-6-enal (CAS 2385-77-5).
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data available as short summary from a secondary source beeing cited in a peer-reviewed publication

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Acute oral toxicity in rats; dermal toxicity in rabbits (2-Isopropyl-5- methyl-2-hexenal; Citronellol; Citronellal; Rhodinol). Unpublished report Nos. 73–197,73–88,73–190,73–150 from MB Research Laboratories, Inc., Perkasie, Pennsylvania, USA. Submitted
Author:
Moreno, O.M.
Year:
1973
Bibliographic source:
cited in: Opdyke DL; Monographs on Fragrance Raw Materials. Citronellal; Food Cosmet Toxicol 13 (SUPPL): 755 (1975).
Reference Type:
secondary source
Title:
Acute oral toxicity in rats; dermal toxicity in rabbits (2-Isopropyl-5- methyl-2-hexenal; Citronellol; Citronellal; Rhodinol). Unpublished report Nos. 73–197,73–88,73–190,73–150 from MB Research Laboratories, Inc., Perkasie, Pennsylvania, USA. Submitted
Author:
Moreno, O.M.
Year:
1973
Bibliographic source:
cited in: RIFM-FEMA Database CAS 106-23-0 RIFM ID 156 FEMA 2307
Reference Type:
secondary source
Title:
Moreno, O.M. (1978) Acute oral toxicity in rats; acute dermal toxicity in rabbits (3,7-Dimethyl- 6-octenoic acid). Unpublished report No. MB 78-2628 from MB Research Laboratories, Inc., Spinnerstown, Pennsylvania, USA. Submitted to WHO by the Flavor and E
Author:
Moreno, O.M.
Year:
1978
Bibliographic source:
WHO FOOD ADDITIVES SERIES: 52 Safety evaluation of certain food additives and contaminants Prepared by the Sixty-first meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Citronellal
EC Number:
203-376-6
EC Name:
Citronellal
Cas Number:
106-23-0
Molecular formula:
C10H18O
IUPAC Name:
3,7-dimethyloct-6-enal
Details on test material:
- Name of test material (as cited in study report): citronellal

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
2500, 5000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 500 - < 5 000 mg/kg bw
Mortality:
3/5 at 5000 mg/kg; 0/5 at 2500 mg/kg
Clinical signs:
other: 5000 mg/kg: lethargy reported in 1/5

Applicant's summary and conclusion