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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Remarks:
The test substance (Citronellal; CAS 106-23-0) represents the racemate of the registered substance (R)-3,7-dimethyloct-6-enal (CAS 2385-77-5).
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data available as short summary from a secondary source beeing cited in a peer-reviewed publication

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Acute oral toxicity in rats; dermal toxicity in rabbits (2-Isopropyl-5- methyl-2-hexenal; Citronellol; Citronellal; Rhodinol). Unpublished report Nos. 73–197,73–88,73–190,73–150 from MB Research Laboratories, Inc., Perkasie, Pennsylvania, USA. Submitted
Author:
Moreno, O.M.
Year:
1973
Bibliographic source:
cited in: Opdyke DL; Monographs on Fragrance Raw Materials. Citronellal; Food Cosmet Toxicol 13 (SUPPL): 755 (1975).
Reference Type:
secondary source
Title:
Acute oral toxicity in rats; dermal toxicity in rabbits (2-Isopropyl-5- methyl-2-hexenal; Citronellol; Citronellal; Rhodinol). Unpublished report Nos. 73–197,73–88,73–190,73–150 from MB Research Laboratories, Inc., Perkasie, Pennsylvania, USA. Submitted
Author:
Moreno, O.M.
Year:
1973
Bibliographic source:
cited in: RIFM-FEMA Database CAS 106-23-0 RIFM ID 156 FEMA 2307
Reference Type:
secondary source
Title:
Moreno, O.M. (1978) Acute oral toxicity in rats; acute dermal toxicity in rabbits (3,7-Dimethyl- 6-octenoic acid). Unpublished report No. MB 78-2628 from MB Research Laboratories, Inc., Spinnerstown, Pennsylvania, USA. Submitted to WHO by the Flavor and E
Author:
Moreno, O.M.
Year:
1978
Bibliographic source:
WHO FOOD ADDITIVES SERIES: 52 Safety evaluation of certain food additives and contaminants Prepared by the Sixty-first meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): citronellal

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
2500, 5000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 500 - < 5 000 mg/kg bw
Mortality:
3/5 at 5000 mg/kg; 0/5 at 2500 mg/kg
Clinical signs:
5000 mg/kg: lethargy reported in 1/5

Applicant's summary and conclusion