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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Remarks:
The test substance (Citronellal; CAS 106-23-0) represents the racemate of the registered substance (R)-3,7-dimethyloct-6-enal (CAS 2385-77-5).
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable study report which meets basic scientific principles. Limitations: test atmosphere generation, analytical verification, only 1 concentration tested

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report Date:
1980

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Inhalation hazard test according to Smyth et al. (1962)
GLP compliance:
no
Test type:
other: BASF Test (Inhalation hazard test)
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): citronellal (3,7-dimethyl-6-octenal)
- Substance-Nr. 78/742

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: water
Details on inhalation exposure:
Test method according to H.F. Smyth et al.: Am. md. Hyg. Ass. J. 23, 95 - 107 (1962)

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION: exposure atmosphere enriched with the test substance at 20 °C
- Source and rate of air: 200 l/hour conducted through the product layer
- System of generating vapour atmosphere: diffusion of 200 l air per hour through a product layer of 5 cm thickness
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
7 h
Concentrations:
Estimated mean concentration: 1.39 mg/l; nominal concentration calculated as quotient of the amount of test substance weight loss during exposure and the amount of air used during exposure (1400 l)
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: unclear if 7 or 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Statistics:
not done

Results and discussion

Mortality:
No mortality observed
Clinical signs:
other: Violent attempts to escape, nuzzling, hydrous nasal discharge, reddened noses, accelerated respiration, insecure gait, scrubby coat, tremor, intermittent respiration
Body weight:
not determined
Gross pathology:
Nothing abnormal detected

Any other information on results incl. tables

Overall mortality: 0/12 after 7 hours of exposure in inhalation hazard test

Applicant's summary and conclusion