4-(2-aminoethyl)phenol

Endpoint summary

Description of key information

Short term toxicity to fish:

Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on fish Danio rerio (previous name: Brachydanio rerio) was predicted for 4-(2-aminoethyl)phenol (Tyramine) (51-67-2). Based on the mortality of fishes, the LC50 value was estimated to be 192.47 mg/l for Danio rerio for 96hrs of duration. Based on this value it can be concluded that the substance 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) is considered to be nontoxic to aquatic environment and not classified as per the criteria mentioned in CLP regulation.

Short term toxicity to aq. invertebrates:

Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the six closest read across substances, toxicity on daphnia magna was predicted for 4-(2-aminoethyl)phenol (Tyramine) (51-67-2). Based on the intoxication of test organism the EC50 value was estimated to be 206 mg/l when 4-(2-aminoethyl)phenol (Tyramine) exposed to daphnia magna for 48 hrs. Based on this value it can be concluded that the substance 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) is considered to be nontoxic to aquatic environment and cannot be classified as per the criteria mentioned in CLP regulation.     

Toxicity to aq. algae and cyanobacteria:

Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, toxicity on Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) predicted 4-(2-aminoethyl)phenol (Tyramine) (51-67-2). Based on the growth rate inhibition the EC50 value was estimated to be 117.4 mg/l when 4-(2-aminoethyl)phenol (Tyramine) exposed to Desmodesmus subspicatus for 72 hrs. Based on this value it can be concluded that the substance 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) considered to be not toxic to aquatic environment and not classified as per the criteria mentioned in CLP regulation.      

Toxicity to microorganisms:

Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, toxicity on microorganism Tetrahymena pyriformis predicted for The IGC50 value was estimated to be 531.2 mg/l when 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) exposed to Tetrahymena pyriformis for 48hrs.

Additional information

Summarized result for the determination of nature of chemical 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) on the growth and other biological and physical activity of fish, aquatic invertebrates, algae and cyanobacteria and microorganisms when chemical comes in contact with test organisms, by considering the data for target as well as structurally and functionally similar read across chemicals which are as follows: 

 

Short term toxicity to fish:

Based on the various predicted data for the target chemical and experimental data for structurally and functionally similar read across chemicals study have been reviewed to determine the toxic nature of target chemical 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) on the growth of fishes. The studies are as mentioned below:   

 

The first weight of evidence for the target chemical 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) from SSS QSAR 2017 prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on fish Danio rerio (previous name: Brachydanio rerio) was predicted for 4-(2-aminoethyl)phenol (Tyramine) (51-67-2). Based on the mortality of fishes, the LC50 value was estimated to be 192.47 mg/l for Danio rerio for 96hrs of duration. Based on this value it can be concluded that the substance 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) is considered to be nontoxic to aquatic environment and not classified as per the criteria mentioned in CLP regulation.

 

Similarly in the second predicted data for (4-(2-aminoethyl)phenol (Tyramine) (51-67-2) ) done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to fish was predicted. On the basis of this programe, the LC 50 value for short term toxicity to fish was predicted to be1196.4 mg/l for 4-(2-aminoethyl)phenol (Tyramine) in 96 hrs. Based on this value it can be concluded that the substance 4-(2-aminoethyl)phenol (Tyramine) is considered to be not toxic to aquatic environment and cannot be classified as per the criteria mentioned in CLP regulation.

 

The third prediction was according to aquatic toxicity module i.e ACD/Labs I-Lab 2.0;Algorithm Version: v5.0.0.184 the lethal concentration (LC50) of the test substance 4-(2-aminoethyl)phenol (Tyramine) was predicted to be 86 mg/l on fish species Fathead minnow (Pimephales promelas). Based on the LC50 calculation the estimated Reliability Index (RI) of test chemical 4-(2-aminoethyl)phenol (Tyramine) predicted to be 0.55 (As per model substance have moderate and high reliability if RI > 0.5).Thus reported RII value indicate it has high reliability. And LC50 value indicate that the test substance 4-(2-aminoethyl)phenol (Tyramine) considered as toxic, harmful to aquatic organisms and thus can be classified in aquatic chronic 3 category as per the CLP criteria. But as the chemical was readily biodegradable in water thus on that basis it is concluded that the chemical was nontoxic and not classified as per the CLP classification criteria.

 

Prediction done using average value of both models i.e Leadscope and SciMatics SciQSAR model and the result were predicted in Battery model. Based on the Danish (Q)SAR Database, the 96hours LC50 was estimated to be 76.05 mg/l on Pimephales promelas for substance 4-(2-aminoethyl)phenol (Tyramine) with mortality effects. Thus based on this value it can be concluded that the substance 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) can be concluded as toxic and classified as aquatic chronic 3 category as per the criteria of CLP regulation. But as the chemical was readily biodegradable in water thus on that basis it is concluded that the chemical was nontoxic and not classified as per the CLP classification criteria.

 

Above predicted data was supported by the fifth experimental weight of evidence study for the read across chemical (105-13-5) from UERL lab 2014. This study was designed to assess the toxic effects of the test compound 4-Methoxy benzyl alcohol on the Zebra fish (Danio rerio). Test was conducted in compliance with the OECD guideline 203. The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 1 g of the test substance in 4 liters of potable water (passed through reverse osmosis system) with continuous stirring for achieving test concentrations of 100 mg/L, respectively. Test conducted at limit test concentration 100 mg/l and Zebra fishes were exposed to this concentration for 96 hours. Test animal was collected from Orange City Aquarium, Sitabuldi, Nagpur, MS (India). 8 fishes exposed to the test concentration. Aeration in test vessels was provided 1 day before the start of experiment. After the exposure of chemical (mortality, visible symptoms, pH, Temperature, dissolved oxygen content) were recorded after 24 hours, 48 hours, 72 hours and 96 hours of the start of the experiment. Based on nominal concentrations, experimental median lethal Concentrations [LC-50 (96 h)] for 4-Methoxy benzyl alcohol CAS No.105-13-5 on Zebra fish (Danio rerio) was determined to be > 100 mg/L by observing the mortality. Thus based on LC50 it can be concluded that the chemical was nontoxic and can be consider to be not classified as per the CLP classification criteria.

 

Similarly in the sixth weight of evidence study for another read across chemical Paracetamol (103-90-2) from UERL lab report short term toxicity was carried out. Based on the nominal concentrations, experimental median lethal concentration [LC-50 (96 h)] for Paracetamol (CAS No. -103-90-2) in Danio rerio was found to be  > 100 mg/L on the basis of mortality effects in a 96 hour study. LC0 (96 hours) (highest concentration at which no mortality was observed) = 100 mg/L. LC50 (96 hours) Experimental = > 100 mg/L. LC100 (96 hours) (lowest concentration at which 100% mortality was observed) = No mortality Thus based on this LC50 value and after comparing with CLP criteria for aquatic classification of the substance it is concluded that the substance Paracetamol does not exhibit toxicity to aquatic fish (Danio rerio).

 

Based on the predicted data for the target chemical (from OECD QSAR 2018 and EPIsuite, Danish QSAR and ACD lab) and for the read across chemical from experimental lab reports (UERL), it can be concluded that the substance 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) is considered to be not toxic to aquatic environment (Fishes) and cannot be classified as toxic as per the criteria mentioned in CLP regulation.    

Short term toxicity to aq. invertebrates:

Based on the various predicted data for the target chemical and experimental data for structurally and functionally similar read across chemicals study have been reviewed to determine the toxic nature of target chemical 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) on the mobility and intoxication of invertebrates. The studies are as mentioned below:   

 

The first weight of evidence for the target chemical 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) from SSS QSAR 2017 prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the six closest read across substances, toxicity on daphnia magna was predicted for 4-(2-aminoethyl)phenol (Tyramine) (51-67-2). Based on the intoxication of test organism the EC50 value was estimated to be 206 mg/l when 4-(2-aminoethyl)phenol (Tyramine) exposed to daphnia magna for 48 hrs. Based on this value it can be concluded that the substance 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) is considered to be nontoxic to aquatic environment and cannot be classified as per the criteria mentioned in CLP regulation.   

 

Similarly in the second predicted data for (4-(2-aminoethyl)phenol (Tyramine) (51-67-2) ) done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of this programe, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 611.3 mg/l for 4-(2-aminoethyl)phenol (Tyramine) in 48 hrs. Based on this value it can be concluded that the substance 4-(2-aminoethyl)phenol (Tyramine) is considered to be not toxic to aquatic environment and cannot be classified as per the criteria mentioned in CLP regulation.  

 

The third study was used from peer reviewed journal (Comparative Biochemistry and Physiology 2009) for target chemical 4-(2-aminoethyl)phenol (Tyramine) (51-67-2). Aim of this study was to determine the effect of chemical 4-(2-aminoethyl)phenol (Tyramine) on the embryonic development, rotation movement and on behavior changes of Lymnaea stagnalis. Test conducted for 7 minutes only. Chemical was analytically monitored by using HPLC. Tyramine were removed from the egg capsules and placed into 1.5 mL microcentrifuge tubes, then homogenized with an ultrasonic homogenizer by 30% pulsed power for 15 s in 100 μL of ice-chilled 0.1 N perchloric acid containing 1 pmol/μL isoproterenol as an internal standard. Assay was repeated three times. Populations of adult L. stagnalis specimens were maintained in aquaria at 20–25 °C, supplied with aerated water. Egg masses were collected from the laboratory populations. The development of L. stagnalis embryos generally takes eight days and can be conveniently monitored through the transparent egg capsules. Test performed at nominal concentrations ranges from 0.13 mg/l to 137.18 mg/l and conducted in 4 replicates. Based on the changes on the distance moved and also change in direct movement of Lymnaea stagnalis (Great Pond Snail), by the chemical4-(2-aminoethyl)phenol (Tyramine), the LOEC was observed at 137.18 mg/l. As the experiment was not performed according to the standard guidelines and the exposure period was very low for the actual determination of effect on the test organisms, thus on that basis chemical was not included for classification.

 

ACD labs predicted median Lethal Concentration (LC50) of daphnia magna using v5.0.0.184. The value is supported by estimated Reliability Index (RI). Based on this, the LC 50 value for test item 4-(2-aminoethyl)phenol (Tyramine) was predicted to be 82 mg/l for Daphnia magna. On the basis of predicted value it can be concluded that the substance 4-(2-aminoethyl)phenol (Tyramine) considered as toxic, harmful to aquatic organisms and thus can be classified in aquatic chronic 3 category as per the CLP criteria. But as the chemical was readily biodegradable in water thus on that basis it is concluded that the chemical was nontoxic and not classified as per the CLP classification criteria.

 

Similarly based on the average value of both models ( Leadscope Enterprise model and SciMatics SciQSAR model), the result were predicted in Battery model. Based on the Danish (Q)SAR Database, the 48 hours EC50 was estimated to be 18 mg/l on Daphnia Magna for substance 4-(2-aminoethyl)phenol (Tyramine) with immobilization effects. Thus based on this value it can be concluded that the substance 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) can be concluded as toxic and classified as aquatic chronic 3 category as per the criteria of CLP regulation. But as the chemical was readily biodegradable in water thus on that basis it is concluded that the chemical was nontoxic and not classified as per the CLP classification criteria.

 

Above predicted data was supported by the fifth experimental weight of evidence study for the read across chemical (99-96-7) from j-check. Determination of short term toxicity of 4-Hydroxybenzoic Acid on the mobility of daphnia magna for 48hrs. Study was performed according to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test. Static method was used for the measurement of toxicity. After the exposure of 48hrs, 50% immobilization was observed at 140 mg/l. Based on the immobilization of daphnia magna due to the exposure of chemical 4-Hydroxybenzoic acid, the EC50 was 140 mg/l. Thus based on the EC50 value it can be concluded that the chemical was nontoxic and can be consider to be not classified as toxic as per the CLP classification criteria.

 

Similarly for the same read across chemical from Water Research 1989 supports the nontoxic nature of chemical. Short term toxicity to Daphnia sp. study was carried out for 48 hrs. Acute Daphnia test was performed according to DIN 38412, Part II. The study was based on the effects of the test compound 4-hydroxy benzoic acid (CAS no. 99-96-7) on Daphnia magna in a static fresh water system at a temperature of 20°C and pH of 8.0±0.2, respectively. Test organism used for the study was 6-24 hr old and no feeding to the organism Daphnia magna was done during the test period. Exact concentration of test chemical used for the study was not known, but the concentration steps of the test solution were selected so as to give 3-4 EC values in a range between EC0 and EC100, of which at least one value was below and one above EC50.The test vessels were two 50 ml beakers and for volatile or strongly smelling substances, two 50 ml bottles with ground-glass stoppers each with 20 ml useful capacity. Two parallel preparations were made for each concentration step. Loading amounted to one test animal per 2 ml test medium as ten 6-24 h old daphnids were placed in each test and control vessel, i.e: 20 animals per concentration step. After a test period of 24 h and again after 48 h, the no. of animals in the control and test solutions that could still swim were counted. After 48 h it was also possible to measure the pH value in order to determine whether the hydrogen ion concentrations were in an acceptable range for the daphnids or whether the result had to be considered as having been influenced by a change in pH during the course of the test. Furthermore, the oxygen content was determined at the end of the test period in order to ensure that it had not fallen below a minimum oxygen concentration of 2 mg/l. The test was considered as valid when fewer than 10% of the animals in the control solutions were unable to swim, when the pH value was not below 7.0 and the O2 value was not below 4.0 m/l. Based on effect on mobility of the test organism Daphnia magna, the 24 hr EC0, EC50 and EC100 value was determined to be 181, 104 and 286 mg/l, respectively and 48 hr EC0, EC50 and EC100 value was determined to be 173, 19 and 204 mg/l, respectively. Thus, based on the 24 and 48 h EC50 value, it can be concluded that the substance 4-hydroxy benzoic acid can be considered as non-toxic to aquatic organisms and thus can be considered to be not classified as per the CLP classification criteria.

 

Based on the predicted data for the target chemical (from OECD QSAR 2018 and EPIsuite, peer reviewed journal (Comparative Biochemistry and Physiology 2009), Danish QSAR and ACD lab) and for the read across chemical from (j-check and Water Research 1989), it can be concluded that the substance 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) is considered to be not toxic to aquatic environment (aquatic invertebrates) and cannot be classified as toxic as per the criteria mentioned in CLP regulation.    

 

Toxicity to aq. algae and cyanobacteria:

Based on the various predicted data for the target chemical and experimental data for structurally and functionally similar read across chemicals study have been reviewed to determine the toxic nature of target chemical 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) on the growth of algae. The studies are as mentioned below:   

 

The first weight of evidence for the target chemical 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) from SSS QSAR 2017 prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, toxicity on Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) predicted 4-(2-aminoethyl)phenol (Tyramine) (51-67-2). Based on the growth rate inhibition the EC50 value was estimated to be 117.4 mg/l when 4-(2-aminoethyl)phenol (Tyramine) exposed to Desmodesmus subspicatus for 72 hrs. Based on this value it can be concluded that the substance 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) considered to be not toxic to aquatic environment and not classified as per the criteria mentioned in CLP regulation.    

Similarly in the second predicted data for (4-(2-aminoethyl)phenol (Tyramine) (51-67-2) ) done by EPI suite, ECOSAR version 1.1 the short term toxicity on green algae was predicted for test substance 4-(2-aminoethyl)phenol (Tyramine) (CAS:51-67-2). On the basis of effects observed in a static freshwater system, the effect concentration EC50 value for the substance is estimated to be 294.4 mg/l for green algae for 96 hrs duration. Based on this value, it can be concluded that the test chemical 4-(2-aminoethyl)phenol (Tyramine) can be considered as non-toxic to green algae at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.

 

 

Based on the prediction done using the three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database, the short term toxicity on green algae was predicted for test substance 4-(2-aminoethyl)phenol; Tyramine (CAS: 51 -67 -2). The average EC50 value was given by the third model i.e, Battery model. On the basis of effects observed in a static freshwater system, the effect concentration EC50 value for the substance 4-(2-aminoethyl)phenol; Tyramine is estimated to be 68.2 mg/l for Pseudokirchneriella subcapitata during 72 hr exposure duration. Thus, on the basis of EC50 value, it can be concluded that the test chemical 4-(2-aminoethyl)phenol; Tyramine can be considered as toxic to green algae at environmentally relevant concentrations and can be considered to be classified in aquatic chronic category 3 as per the CLP classification criteria. But as the chemical was readily biodegradable in water thus on that basis it is concluded that the chemical was nontoxic and not classified as per the CLP classification criteria.

 

Above predicted data was supported by the fourth experimental weight of evidence study for the read across chemical (105-13-5) from UERL lab 2014. This study was designed to assess the toxic effects of the test compound 4-methoxyphenyl)methanol (105 -13 -5) on the growth of green alga Chlorella vulgaris. The study was conducted following OECD guideline 201- Alga, growth inhibition test. The test concentration chosen for the study were 6.25mg/l, 12.5mg/l, 25mg/l, 50mg/l, 100mg/l and 200mg/l. All the tests were carried out in 100mL conical flasks which were carefully autoclaved and sterilized. The test solution in each of these test vessels was kept constant which is 60 ml so that a sufficient amount of head space was left. The test solution was prepared in aseptic condition. The test substance 4-methoxybenzyl alcohol was prepared by adding 60 µl of test substance in 300 ml of BBM to get the final concentration of 200 mg/L. The remaining test solutions were prepared by dilution from the above stock solution. To have a better growth and visibility of cells, the initial cell density of the culture was kept 1 X 104 cells/ml. Care was taken to have a homogeneous solution for the experiment. For the assessment of algal growth, the test was conducted in replicates. The control flask was maintained in triplicates as recommended in the OECD guideline and the test concentration were selected in geometric series which were maintained in duplicates. To obtain a quantitative concentration-response relationship by regression analysis, a linearizing transformation of the response data into probit was performed. Using the same, effective concentration (EC) were determined. After 72 hours of exposure to test item 4-methoxyphenyl)methanol to various nominal test concentrations, EC50 was determine to be >200mg/l and the EC10 was determine to be 158.49 mg/l graphically and through probit analysis. Based on the EC50, it can be consider that the chemical was nontoxic and can be consider to be not classified as per the CLP classification criteria.

Similarly in the fifth weight of evidence study for another read across chemical Paracetamol (103-90-2) from UERL lab report short term toxicity was carried out. The effect of test item paracetamol, CAS No. 103-90-2 was studied on the growth of fresh water green alga Chlorella vulgaris. The study was conducted following OECD guideline 201- Alga, growth inhibition test. The test concentration chosen for the study were 6.25mg/l, 12.5mg/l, 25mg/l, 50mg/l, 100mg/l and 200mg/l. The test concentrations were prepared using stock solution of the test item using mineral media. The green alga was exposed to the test concentration for a period of 72 hours to observe average specific growth rate and % growth inhibition under the effect of the test item. EC50 calculated graphically through probit analysis was observed to be 112.666mg/l. Based on this EC50 value and after comparing with CLP criteria for aquatic classification of the substance it is concluded that the substance Paracetamol does not exhibit toxicity to aquatic algae (Chlorella vulgaris).

 

Based on the predicted data for the target chemical (from OECD QSAR 2018 and EPIsuite, Danish QSAR) and for the read across chemical from experimental lab reports (UERL), it can be concluded that the substance 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) is considered to be not toxic to aquatic environment (aquatic algae) and cannot be classified as toxic as per the criteria mentioned in CLP regulation.   

 

Toxicity to microorganisms:

Based on the various predicted data for the target chemical and experimental data for structurally and functionally similar read across chemicals study have been reviewed to determine the toxic nature of target chemical 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) on the growth of microorganisms. The studies are as mentioned below:   

 

The first weight of evidence for the target chemical 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) from SSS QSAR 2017 prediction done done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, toxicity on microorganism Tetrahymena pyriformis predicted for The IGC50 value was estimated to be 531.2 mg/l when 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) exposed to Tetrahymena pyriformis for 48hrs.

 

First predicted data was supported by the second experimental weight of evidence study for the read across chemical (106-44-5) from authoritative database (HSDB and ECOTOX 2018). Aim of this study was to assess the effect of chemical p-cresol on the growth of microorganisms Tetrahymena pyriformis (Ciliate). Test conducted under the static system for total exposure period of 48 hrs. ≥ 3 replicates were used. Based on the population growth rate inhibition of test organism Tetrahymena pyriformis (Ciliate) due to the chemical p-cresol, the IC50 was determine to be 157 mg/l. Thus based on the IC50, chemical p-cresol was consider as nontoxic.

 

Similarly in the third weight of evidence study for another read across chemical (105-13-5) from handbook or collection of data 2011 study was conducted. Aim of this study was to determine the nature of chemical on the growth of microorganisms. Oleaginous yeast, Lipomyces starkeyi (IFO10381) was maintained on YM agar. The compound as a methanol solution was added to 5 mL of broth in a test tube to produce final concentrations of 20 or 200 mg/L compound and 1% (v/v) methanol at the start of the culture. As a control, 1% methanol was added to the broth. Yeasts were cultivated using a rotary shaker (120 rpm) at 27 °C for 7 days. The compound as a methanol solution was added to 5 mL of broth in a test tube to produce final concentrations of 20 or 200 mg/L compound and 1% (v/v) methanol at the start of the culture. As a control, 1% methanol was added to the broth. Yeasts were cultivated using a rotary shaker (120 rpm) at 27 °C for 7 days. Antifungal activity of 4-methoxybenzyl alcohol was tested at the dose concentrations of 20 and 200 mg/L on the fungi Lipomyces starkeyi IFO10381 for a duration of 7 days. The substance inhibited fungal growth by 14% at both concentrations.

 

Based on the overall studies for the target chemical 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) from QSAR toolbox 2018 and for the read across chemical from HSDB and ECOTOX 2018 and handbook or collection of data 2011, chemical was consider as nontoxic.

 

Thus based on the overall studies of toxicity of chemical 4-(2-aminoethyl)phenol (Tyramine) (51-67-2 on the growth of aquatic fishes, aquatic invertebrates and algae, it can be concluded that the substance 4-(2-aminoethyl)phenol (Tyramine) (51-67-2) is considered to be not toxic to aquatic environment (aquatic algae) and cannot be classified as toxic as per the criteria mentioned in CLP regulation.