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Diss Factsheets

Administrative data

Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Title:
Unnamed
Year:
2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC estimation method
Media:
soil/sewage sludge

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(1,3-benzodioxol-5-ylamino)ethanol hydrochloride
EC Number:
303-085-5
EC Name:
2-(1,3-benzodioxol-5-ylamino)ethanol hydrochloride
Cas Number:
94158-14-2
Molecular formula:
C9H11NO3.ClH
IUPAC Name:
2-(1,3-benzodioxol-5-ylamino)ethanol hydrochloride
Test material form:
solid: crystalline
Radiolabelling:
no

Study design

Test temperature:
25 °C

Results and discussion

Adsorption coefficientopen allclose all
Key result
Sample No.:
#1
Type:
log Koc
Value:
1.14 dimensionless
pH:
9
Temp.:
25 °C
Sample No.:
#2
Type:
Koc
Value:
14.1 dimensionless
Sample No.:
#3
Type:
Koc
Value:
13.5 dimensionless
Sample No.:
#4
Type:
Koc
Value:
13.5 dimensionless

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The estimated value of log Koc for the test item AMINOL was determined to be 1.14 ± 0.012 corresponding to a Koc of 13.7.
Acc. to the MCCALL-classification scheme of soil mobility potential a Koc of 13.7 would mean very high mobility for AMINOL in soil.
Executive summary:

The estimation of the adsorption coefficient (Koc) on soil and on sewage sludge using high performance liquid chromatography (HPLC) was carried out according to the principles of OECD/OCDE-Guideline No. 121 (adopted 2001-01-22) for the test item AMINOL (batch number: R0075037) on 2003-06-11 at the DR.U.NOACK·lABORATORIEN, Sarstedt, Germany. The test was conducted with a test item concentration of 5 mg/L in mobile phase of 45 % acetonitrile and 55 % borate-buffer pH 9.0. Samples of the test item AMINOL were analysed threefold via HPLC on a cyanopropyl (CN-) column with UV - detection. Calibration was performed using six reference items with known values of log Koc (values from batch equilibrium experiments given in literature), each with a nominal concentration of 5 mg/L in mobile phase. Analysis of the reference items were performed once before and after analysis of test item, respectively. Dead time of the HPLC-system was determined threefold using 5 mg/L sodium nilrate in mobile phase. For calibration data and details see part 4.2.