Registration Dossier
Registration Dossier
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EC number: 208-144-8 | CAS number: 512-56-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- method of Draize and associates: only 4 animals used, number of dose levels not mentioned
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding toxicity data: List VII
- Author:
- Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C., Striegel, J.A., Nycum J.S.
- Year:
- 1 969
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J., 1969, 30:5, 470-476
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth H.F., Carpenter C.P., Weil C.S., Pozzani U.C., Striegel J.A.
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J., 1962, 23:2, 95-107
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Trimethyl phosphate
- EC Number:
- 208-144-8
- EC Name:
- Trimethyl phosphate
- Cas Number:
- 512-56-1
- Molecular formula:
- C3H9O4P
- IUPAC Name:
- trimethyl phosphate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 - 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Type of wrap if used: impervious plastic film
- Duration of exposure:
- 24 hour contact period
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- LD50 value and its fiducial range are estimated by the method of Thompson using the Tables of Weil.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 388 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP criteria not met
- Conclusions:
- The LD50 dermal of Trimethyl phosphate is 3388 mg/kg bw.
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