Registration Dossier

Administrative data

Description of key information

Guidelined oral and dermal study in rats. Under the experimental conditions employed the LD50 was calculated to be 1564 mg/kg bw and 1436 mg/kg bw in male and female rats respectively. The substance 2-((4-methyl-2-nitrophenyl)amino)ethanol was classified as acute toxicity (oral) category 4.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
1 436 mg/kg bw
Quality of whole database:
reliable without restriction

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
2 000 mg/kg bw
Quality of whole database:
reliable without restriction

Additional information

Justification for classification or non-classification

LD50 (oral) is between 300 and 2000 mg/kg bw, Hydroxyethyl-2-nitro-p-toluidine is therefor to be classified according to (EG) Nr. 1272/2008 (CLP) as Acute Tox. 4 ( H302: Harmful if swallowed).

LD50 (dermal) is higher than 2000 mg/kg bw, Hydroxyethyl-2-nitro-p-toluidine is therefore not to be classified.