Registration Dossier
Registration Dossier
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EC number: 214-011-5 | CAS number: 1072-62-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1967-07-04 - 1967-07-11
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic information given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylimidazole
- EC Number:
- 214-011-5
- EC Name:
- 2-ethylimidazole
- Cas Number:
- 1072-62-4
- Molecular formula:
- C5H8N2
- IUPAC Name:
- 2-ethylimidazole
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: "Kisslegg" mice
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- Form of application: solution
Concentrations used: 2, 4, 8 and 16% (w/v) - Doses:
- 200, 250, 320, 400, 500, 800 and 1600 mg/kg
- No. of animals per sex per dose:
- 10 per dose level
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 400 mg/kg bw
- Mortality:
- 200, 250 and 320 mg/kg: no deaths; 400 mg/kg: 5/10 after 7 days; 500 mg/kg: 8/10 after 7 days; 800 and 1600 mg/kg: 10/10 after 7 days
- Clinical signs:
- Dyspnea, apathy, staggering, abdominal and lateral position, convulsions
- Gross pathology:
- Animals that died: 1 x adherences between liver and stomach
Sacrificed animals: mot animals with adherences or adhesions, 3 x spotty-paled liver
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
