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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
Comparable to guideline study with acceptable restrictions (prior to GLP, reporting deficiencies)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Principles of method if other than guideline:
Internal test method: A single group of 5 sprague Dawley rats/sexes were treated by gavage of the test substance in aqueous solution. Animal weights were monitored continuously. The animals were observed for mortality and for clinical signs of toxicity for a period of 14 days. Animals that died during the observations period were subjected to necropsy. At the end of the observation period, the surviving animals were sacrificed for the purpose of necropsy.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3,10-bis(2-methylpropyl) perylene-3,10-dicarboxylate; 3,9-bis(2-methylpropyl) perylene-3,9-dicarboxylate
EC Number:
616-749-7
Cas Number:
79869-59-3
Molecular formula:
C30H28O4
IUPAC Name:
3,10-bis(2-methylpropyl) perylene-3,10-dicarboxylate; 3,9-bis(2-methylpropyl) perylene-3,9-dicarboxylate
Details on test material:
- Analytical purity: 100%
- Name of test material (as cited in study report): Fluorolgruengold Misch. Nr. 27-3887

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 210 g (m), 160g (f), average weights

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
CMC (carboxymethyl cellulose)
Details on oral exposure:
VEHICLE
- Concentrationin vehicle: 30% suspension in 0.5% CMC in aqueous solution


MAXIMUM DOSE VOLUME APPLIED: 15.45 ml/kg bw
Doses:
10000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of weighing: before administration, 2nd, 7th and 13th day after
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Remarks on result:
other: no mortality occurred
Mortality:
no mortality observed
Clinical signs:
other: no clinical signs of toxicity were observed
Gross pathology:
No adverse pathological findings at necropsy

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met