Registration Dossier
Registration Dossier
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EC number: 605-146-4 | CAS number: 158451-78-6
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The 3-h EC10 value is > 1000 mg/L active ingredient (corresponding to 5780 mg/L test substance) observed in a respiration inhibition study with activated sludge of a predominantly domestic sewage.
Key value for chemical safety assessment
Additional information
The toxicity of the substance to microorganisms was investigated in an activated sludge respiration inhibition study according to OECD TG 209 and in compliance with GLP criteria. In this study activated sludge from a predominantly domestic sewage was exposed to nominal test substance concentrations of 62.5, 125, 250, 500 and 1000 mg/L active ingredient (corresponding to nominal test substance concentrations of 361, 723, 1445, 2890 and 5780 mg/L) for 3 hours. Test concentrations were not analytically verified. The effects on microorganisms was determined by measuring total respiration rates and comparing these to an unexposed control. In the test a slight promotion, rather than inhibition of respiration was observed at all test concentrations. Therefore the EC10 value is assumed to be greater than 1000 mg/L active ingredient (corresponding to 5780 mg/L test substance).
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