Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
No information
Author:
CAUJOLLE, MEYNIER and MOSCARELLA
Year:
1953
Bibliographic source:
C R Hebdo Seanc Acad Sci, Paris, 236, 2549 (citation)
Reference Type:
review article or handbook
Title:
No information
Author:
CLAYTON GD, CLAYTON FE
Year:
1993
Bibliographic source:
Patty's Industrial Hygiene and Toxicology , 4th Edit Vol II.A, 445-525
Reference Type:
secondary source
Title:
No information
Author:
OPDYKE DLJ
Year:
1977
Bibliographic source:
Food Cosmet Toxicol, 15(6), 633-638
Reference Type:
secondary source
Title:
No information
Author:
CAUJOLLE, MEYNIER and FARTHOUAT
Year:
1956
Bibliographic source:
C R Hebdo Seanc Acad Sci, Paris, 243, 609 (citation)
Reference Type:
secondary source
Title:
No information
Author:
CAUJOLLE, MEYNIER and MOSCARELLA
Year:
1953
Bibliographic source:
C R Hebdo Seanc Acad Sci, Paris, 236, 2549 (citation)
Reference Type:
secondary source
Title:
No information
Author:
FRAZER
Year:
1967
Bibliographic source:
FAO/OMS Report Ser, vol 44A, 78 (citation)

Materials and methods

Principles of method if other than guideline:
See results
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Vanillin
EC Number:
204-465-2
EC Name:
Vanillin
Cas Number:
121-33-5
Molecular formula:
C8H8O3
IUPAC Name:
1-butoxypropan-2-ol
Details on test material:
no data

Test animals

Species:
other: see results

Administration / exposure

Route of administration:
other: see results

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 160 mg/kg bw
Remarks on result:
other: rat by i.p. route
Sex:
not specified
Dose descriptor:
LD50
Effect level:
780 mg/kg bw
Remarks on result:
other: mouse by i.p. route
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 190 mg/kg bw
Remarks on result:
other: guinea pig by i.p. route
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
1 320 mg/kg bw
Remarks on result:
other: dog by i.v. route
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 500 mg/kg bw
Remarks on result:
other: rat by s.c. route

Applicant's summary and conclusion