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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Acute oral toxicity study for CAS no: 40880-51-1
Author:
U.S .National library of medicine
Year:
2017
Bibliographic source:
ChemID plus A TOXNET DATABASE.2017

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of 3-[[4-[(2-chloro-4-nitrophenyl)azo]phenyl]ethylamino]propiononitrile was performed in mouse.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report):3-[[4-[(2-chloro-4-nitrophenyl)azo]phenyl]ethylamino]propiononitrile
- Molecular formula :C17H16CIN5O2
- Molecular weight :357.799g/mole
- Substance type:organic
- Physical state:No data available
-Purity:No data available
- Impurities (identity and concentrations):No data available
Specific details on test material used for the study:
Name of test material (as cited in study report):3-[[4-[(2-chloro-4-nitrophenyl)azo]phenyl]ethylamino]propiononitrile
- Molecular formula :C17H16CIN5O2
- Molecular weight :357.799g/mole
- Substance type:organic
- Physical state:No data available
-Purity:No data available
- Impurities (identity and concentrations):No data available

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
10000mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be >10000mg/kg body weight. When mouse was treated with 3-[[4-[(2-chloro-4-nitrophenyl)azo]phenyl]ethylamino]propiononitrile (40880-51-1) orally.
Executive summary:

Acute oral toxicity study was done in mouse using3-[[4-[(2-chloro-4-nitrophenyl)azo]phenyl]ethylamino]propiononitrile(40880-51-1). No mortality was observed at dose 10000mg/kg bw.Hence LD50 was considered to be >10000mg/kg body weight. When mouse was treated with 3-[[4-[(2-chloro-4-nitrophenyl)azo]phenyl]ethylamino]propiononitrile(40880-51-1)orally.