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EC number: -
CAS number: -
No skin sensitizing properties were observed in a LLNA.
Compared to vehicle-treated animals, also none of the other parameters
measured in the substance-treated groups, i.e. weights of the draining
lymph nodes, ear weights and ear swelling, reached or exceeded the
"positive levels" defined for this assay.
weight index: 1.00 (0 %) / 0.85 (2 %) / 0.96 (10 %) / 0.93 (50 %)
ear swelling: day 1 = 17.75 (0 %) / 17.75 (2 %) / 18.25 (10 %) / 17.83
(50 %); day 4 = 18.00 (0 %) / 18.00 (2 %) / 18.42 (10 %) / 18.25 (50 %); Index
day 4 = 1.00 (0 %) / 1.00 (2 %) / 1.02 (10 %) / 1.01 (50 %)
ear weight: day 4 = 13.66 (0 %) / 13.43 (2 %) / 12.96 (10 %) / 13.16 (50
%); Index day 4 = 1.00 (0 %) / 0.98 (2 %) / 0.95 (10 %) / 0.96 (50 %).
The body weights of the animals were not affected by any treatment. This
study does neither point to a non-specific (irritant) nor to a specific
irnmunostimulating (sensitizing) potential of the test item.
A modified LLNA (IMDS; OECD TG 429) was performed on 6 female NMRI mice
per dose group using epicutaneously applied test substance of 0 %
(vehicle control), 2 %, 10 % and 50 %. The study does neither point to a
non-specific (irritant) nor to a specific immunostimulating
(sensitizing) potential of the test item. Therefore, the concentration
of 50 % turned out to be the NOEL for the parameters investigated
(weight and cell counts of the draining lymph nodes, ear swelling, ear
weight) with respect to skin sensitization.
According to an LLNA (Modification: conducted as IMDS; OECD TG 429) the
test substance does neither have a non-specific (irritant) nor a
specific immunostimulating (sensitizing) potential.
No classification required for sensitization according to Regulation
(EC) No 1272/2008, Annex I.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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