Registration Dossier
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EC number: 226-558-7 | CAS number: 5424-01-1
Surface tension
Administrative data
- Endpoint:
- surface tension
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 February 2013 - 28 March 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study has been performed in accordance with the EC A.5 and OECD 115 guidelines and complied with the principles of GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.5 (Surface Tension)
- Version / remarks:
- (2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 115 (Surface Tension of Aqueous Solutions)
- Version / remarks:
- (1995)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- OECD harmonised ring method
Test material
- Reference substance name:
- 3-aminopyrazine-2-carboxylic acid
- EC Number:
- 226-558-7
- EC Name:
- 3-aminopyrazine-2-carboxylic acid
- Cas Number:
- 5424-01-1
- Molecular formula:
- C5H5N3O2
- IUPAC Name:
- 3-aminopyrazine-2-carboxylic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Amiloride Compound 5
- Description: Tan powder
- Storage condition of test material: In refrigerator (2-8°C) protected from light, desiccated
- Other: Reactive to light, moisture and oxygen
Constituent 1
Results and discussion
Surface tension
- Surface tension:
- 73.6 mN/m
- Temp.:
- 20 °C
- Conc.:
- 1 g/L
Any other information on results incl. tables
Surface tension measurements
Measurement
|
Time passed [minutes] |
Surface tension [mN/m] |
||
individual |
Mean (1) |
mean corrected (2) |
||
1 |
23 |
73.2 |
72.9 |
73.6 |
2 |
24 |
72.4 |
||
3 |
25 |
73.0 |
||
4 |
26 |
72.9 |
||
5 |
28 |
72.8 |
||
6 |
29 |
72.9 |
||
7 |
30 |
72.9 |
||
(1) Mean calculated from measurements 3 to 7
(2) Multiplied by the calibration factor followed by correction according to Harkins-JordanApplicant's summary and conclusion
- Conclusions:
- The surface tension of an aqueous solution of the substance at 1 g/L was determined to be 73.6 mN/m at 20°C using the OECD Harmonized ring method (GLP-compliant study in accordance with EC A.5 and OECD 115). Because this is not < 60 mN/m, Amiloride Compound 5 is not surface active according to the EC A.5 guideline.
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