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EC number: 300-523-7
CAS number: 93941-74-3
toxicity test were performed on mice with different concentrations from 0.1,
0.25,0.5 or 1.0% (130,325,650,1300 mg/kg bw/d)Black
PN for 80 wk. 30 males and 30 females was used for the treatment and
group of 60 mice of each sex as control. The
general condition and behaviour of the animals were observed frequently
and any mouse that showed signs of ill-health was isolated, to be
returned to its cage on recovery or to be killed if its condition
deteriorated. The mice were weighed at the start of the experiment, at
wk 3 and then at intervals of 2 wk until wk 73 of the experiment. Blood
sample were taken at wk 28 and 55.At
80 wk, blood samples were collected from the aorta of all surviving mice
during the autopsy. For haematology blood samples were collected and for
urine sample from 6-hr period from three groups of five mice of each sex
from the controls and the groups on the two highest dietary levels of
Black PN. Histopathology was also conducted. There
were no dose-related effects on body-weight gain, haematology or organ
weights. The incidence of histopathological findings, including tumours,
was not altered by the feeding of Black PN. Therefore,
the endpoint for the repeated dose toxicity was found to be NOAEL at 1 %
(1300 mg/kg/day) concentration of Black PN to mice.
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