Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April 21-May 17 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report Date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: Knudsen cell

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Type:
Constituent
Type:
Constituent
Type:
Constituent
Type:
Constituent
Type:
Constituent
Test material form:
liquid
Specific details on test material used for the study:
Name (as stated in the report): VETYNAL
Batch: VE00473596
Expiration date: March 05, 2019

Results and discussion

Vapour pressureopen allclose all
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0.362 Pa
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
0.527 Pa

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the test item VETYNAL was determined at three different temperatures (30, 45 and 60°C) following EU A.4 using the effusion method (weight loss). When visible contaminations, caused by explosive evaporation of the test item, were observed, the cells were meticulously cleaned and weighed. To avoid bias, these measurements were not used for calculations.

Three experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good reproducibility, giving relative standard deviations of less than 20 % (limit value from the guideline 30 %) and good correlation. Therefore, the result of the test can be considered valid.
Executive summary:

The vapour pressure of VETYNAL was determined following EU A.4 using the effusion method (weight loss).

Vapour pressure was examined at three different temperatures. Three temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (P).

The graph 1/T vs. log (P) shows a straight line with a correlation coefficient of - 0.9999.

For the test item VETYNAL, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C: 0.362 Pa

Vapour pressure at 25 °C: 0.527 Pa