Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Respiratory sensitisation

Experimental data on respiratory sensitisation of Flurbiprofen t-butyl ester are not available.

As a results of the profiling of the substance performed by means QSAR Toolbox, structural alerts were not found.

 

Overall, available data are inconclusive for the classification of the substance.

Skin sensitisation

Experimental data on skin sensitisation of Flurbiprofen t-butyl ester are not available.

 

QSAR Toolbox has identified one structural alert for the protein binding potency h-CLAT (human cell line activation), this alert is the "Monohaloarenes". By contrast, considering that (i) the ability of substance to react with proteins (Direct Peptide Reactivity Assay (DPRA)) during adverse outcome pathway (AOP) for skin sensitization is considered "non reactive" because one halogen is too weak to take part of SNAr reactions, (ii) structural alerts were not found for the "Protein binding alerts for skin sensitisation (GHS)"/"Protein binding alerts for skin sensitisation (OESIS)" and (iii) Toxtree model confirmed "No skin sensitisation reactivity domains alerts identified"; available data are inconclusive for the classification of the substance.