Registration Dossier
Registration Dossier
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EC number: 217-925-2 | CAS number: 2009-83-8
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- Commission Regulation (EC) No 440/2008 (as amended) of 30 May 2008
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Type:
- Pow
- Partition coefficient:
- 71.6
- Temp.:
- 30 °C
- pH:
- ca. 7
- Details on results:
- The result from the preliminary estimate indicated that the HPLC method was suitable for determination of partition coefficient for this test item.
The calibration curve for the reference standards showed good first order correlation. The chromatography of the test item showed a peak with a
reproducible retention time. The HPLC method was therefore considered to be suitable for the purpose of the study. Based on the chromatographic data,
the test item was considered to be stable during the test procedure.
Approximately neutral pH was considered sufficient to ensure a non-ionized molecular form of the test item. Therefore, no specific manipulation of the
mobile phase pH was necessary. - Conclusions:
- The partition coefficient (n-octanol/water) of Chlorohexanol has been determined to be 71.6 (log10 Pow 1.86).
- Executive summary:
The partition coefficient (n-octanol/water) of Chlorohexanol has been determined to be 71.6, log10 Pow 1.86, using a high performance liquid chromatography (HPLC) method, designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
Reference
Description of key information
The partition coefficient (n-octanol/water) of Chlorohexanol has been determined to be 71.6,
log10 Pow 1.86, using a high performance liquid chromatography (HPLC) method, designed to
be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No
440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of
Chemicals, 13 April 2004.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.86
- at the temperature of:
- 30 °C
Additional information
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