Registration Dossier
Registration Dossier
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EC number: 200-023-8 | CAS number: 50-28-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 2.48 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 2.48 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Validity criteria fulfilled:
- yes
- Conclusions:
- Estradiol is not toxic to the green algae Desmodesmus subspicatus
- Executive summary:
Estradiol was incubated in an aqueous solution with an algae population of Desmodesmus subspicatus for a duration of 72 hours; the algae were exposed to each concentration in triplicate. Six vessels were prepared for the control. The algae were incubated under continuous light, and controlled temperature. The study was conducted according to OECD 201.
Results: ZK 5018 had no concentration-dependend inhibitory effect on the growth of Desmodesmus subspicatus. The EC50 (growth rate) was higher than a saturated solution (3.1 mg/L).
Reference
Estradiol has no concentration dependent inhibitory effect on growth rate and biomass of the algae. The EC50 (biomass) and EC50 (growth rate) was higher than the saturated solution (3.1 mg/l).
Description of key information
Estradiol was incubated in an aqueous solution with an algae population of Desmodesmus subspicatus for a duration of 72 hours; the algae were
exposed to each concentration in triplicate. Six vessels were prepared for the control. The algae were incubated under continuous light, and
controlled temperature. The study was conducted according to OECD 201.
Results: ZK 5018 had no concentration-depended inhibitory effect on the growth of Desmodesmus subspicatus. The EC50 (growth rate) was higher
than a saturated solution (3.1 mg/L).
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 3.1 mg/L
Additional information
The study was performed under GLP (report A30506)
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