Registration Dossier
Registration Dossier
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EC number: 215-885-0 | CAS number: 1443-80-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Authoritive database
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Skin irritation for CAS NO: 119-61-9
- Author:
- IFA (GESTIS)
- Year:
- 2 017
- Bibliographic source:
- GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- An eye irritation study of Benzophenone was conducted in rabbits to assess the irritation potential
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzophenone
- EC Number:
- 204-337-6
- EC Name:
- Benzophenone
- Cas Number:
- 119-61-9
- Molecular formula:
- C13H10O
- IUPAC Name:
- Benzophenone
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): Benzophenone
- Molecular formula: C13H10O
- Molecular weight: 182.22 g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Benzophenone
- Molecular formula: C13H10O
- Molecular weight: 182.22 g/mol
- Substance type: Organic
- Physical state: Solid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 0.1mL
- Duration of treatment / exposure:
- No Data Available
- Observation period (in vivo):
- No Data Available
- Duration of post- treatment incubation (in vitro):
- No Data Available
- Number of animals or in vitro replicates:
- No Data Available
- Details on study design:
- No Data Available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation was observed.
- Other effects:
- No Data Available
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- The test material Benzophenone (CAS No: - 119-61-9) was considered to be not irritating to rabbits’ eye.
- Executive summary:
An eye irritation study of Benzophenone (CAS No: -119-61-9)was performed in rabbits to assess its effects in rabbits’ eye.
The test substance was placed in rabbit’s eye at volume of 0.1ml and observed for any ocular changes.
Since the chemical did not induce any adverse effects, Benzophenone (CAS No: -119-61-9)was considered to be not irritating to rabbits’ eye.
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