Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-529-8 | CAS number: 479-27-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The test substance 1,8-naphylenediamine was evaluated for potential skin sensitizing properties in a maximisation test as decribed by Magnusson and Kligman. The test was performed on male guinea pigs. The following test compound concentrations were used in this test:
Intradermal induction: 5 %
Topical induction: 50 %
Challenge: 50% and 25 %
After the challenge with a 50% suspension all animals revealed a positive reaction, and after the challenge with a 25% suspension 80% of the animals revealed a positive reaction. In the control group no reaction was observed.
Therefore a classification as Xi, R43 (GHS: Skin Sens.1B) ist justified.
Migrated from Short description of key information:
In a valid study 1,8-naphthylenediaminewas tested in a guinea pig maximisation test (GPMT) as described by Magnusson and Kligman
Justification for selection of skin sensitisation endpoint:
Key study used
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
no data
Justification for classification or non-classification
In the skin sensitization test according Magnusson and Kligman, after the challenge with a 50% suspension 100% of the animals revealed a positive reaction, and after the challenge with a 25% suspension 80% of the animals revealed a positive reaction. In the control group no reaction was observed.
Therefore a classification as Xi, R43 (GHS: Skin Sens.1B) ist justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
