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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Specific investigations: other studies

Currently viewing:

Administrative data

Endpoint:
biochemical or cellular interactions
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: special investigation

Data source

Reference
Reference Type:
publication
Title:
Brief communication: In vivo effect of some naphthalene-related compounds on Aryl Hydrocarbon (Benzo[a]pyrene) hydroxylase
Author:
Alexandrov K, Frayssinet C
Year:
1973
Bibliographic source:
J Natl Cancer Inst 51, 1067-1069 (1973)

Materials and methods

Principles of method if other than guideline:
The effects of naphthalene and related compounds on AHH activity was measured
GLP compliance:
no
Type of method:
in vivo

Test material

Constituent 1
Chemical structure
Reference substance name:
1,8-naphthylenediamine
EC Number:
207-529-8
EC Name:
1,8-naphthylenediamine
Cas Number:
479-27-6
Molecular formula:
C10H10N2
IUPAC Name:
naphthalene-1,8-diamine

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
coconut oil
Duration of treatment / exposure:
injection on 3 consecutive days
Frequency of treatment:
daily
Post exposure period:
animals were killed 24 hours after the last injection
Doses / concentrations
Remarks:
Doses / Concentrations:
40 mg/kg
Basis:

No. of animals per sex per dose:
no data
Control animals:
yes, concurrent vehicle

Results and discussion

Details on results:
In the liver the AHH activity was not increased, however in the lung and kidney an increase of AHH activity was observed.

Applicant's summary and conclusion

Executive summary:

AHH (Aryl hydrocarbon (benzo[a]pyrene) hydroxylase) activity was measuredin liver, lung and kidney (homogenate and microsomes) of rats. In the liver the AHH activity was not increased, however in the lung and kidney an increase of AHH activity was observed.