Registration Dossier
Registration Dossier
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EC number: 209-052-0 | CAS number: 553-86-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The test substance revealed positive results in LLNA (EC3: 0.3%).
In a GPMT the outcome was considered to be ambiguous, due to the high rate of positive reactions in the negative control animals. Nevertheless the test substance caused 100% positive reactions in the dose group. Accordingly these results are not contradictory to the outcome of the LLNA.
Based on these data test substance was considered to be a skin sensitizer.
Migrated from Short description of key information:
OECD 429 LLNA (KEY_429_2004_NOTOX_415788): positive
OECD 406 GPMT (NON-KEY_406_2001_NOTOX_327577): ambiguous
Justification for classification or non-classification
Positive results in a LLNA and ambiguous but not contradictory findings in a GPMT meet criteria for classification according to 67/548/EEC (2.2 DSD-DPD) or REGULATION (EC) No 1272/2008 (2.1 GHS). Therefore classification as R43 May cause sensitization by skin contact or Skin Sensitisation Category 1 (H317: May cause an allergic skin reaction) is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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