Registration Dossier

Administrative data

Description of key information

An in vitro skin corrosion assay according to OECD guideline 431 is available for TPnB-highers.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

TPnB-H Glycol Ether was evaluated for skin corrosivity potential in an EpiDerm In Vitro corrosion assay which utilizes cultured human epidermal cells. In this assay, test material was topically applied to a three-dimensional regenerated human epidermis tissue for three minutes or one hour. Skin corrosion potential of the test substance was classified according to tissue viability following exposure. A test substance is considered corrosive if the mean viability is less than 50% after three minutes or ≥ 50% at three minutes but less than 15% after one hour. The mean tissue viability of DOWANOL™ TPnB-H Glycol Ether treatment following the three minute and one hour exposure periods were 89.2% and 92.6% respectively. Therefore, using the EpiDerm prediction model for corrosion DOWANOL™ TPnB-H Glycol Ether was classified as non-corrosive.

No eye irritation test has been conducted with TPnB-highers as the reaction mass contains up to 2 % potassium hydroxide and is therefore classified for skin and eye irritation.


Effects on skin irritation/corrosion: irritating

Effects on eye irritation: irritating

Justification for classification or non-classification

TPnB-H Glycol Ether was classified as non-corrosive based on the results from an in vitro model for skin corrosion. Due to residual alkalinity (potassium hydroxide) and pH >11.5 TPnB-highers are classified for skin and eye irritation.