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EC number: 500-003-1
CAS number: 9003-13-8
An in vitro skin corrosion assay according to OECD guideline 431 is available for TPnB-highers.
TPnB-H Glycol Ether was evaluated for skin corrosivity potential in an
EpiDerm In Vitro corrosion assay which utilizes cultured human epidermal
cells. In this assay, test material was topically applied to a
three-dimensional regenerated human epidermis tissue for three minutes
or one hour. Skin corrosion potential of the test substance was
classified according to tissue viability following exposure. A test
substance is considered corrosive if the mean viability is less than 50%
after three minutes or ≥ 50% at three minutes but less than 15% after
one hour. The mean tissue viability of DOWANOL™ TPnB-H Glycol Ether
treatment following the three minute and one hour exposure periods were
89.2% and 92.6% respectively. Therefore, using the EpiDerm prediction
model for corrosion DOWANOL™ TPnB-H Glycol Ether was classified as
No eye irritation test has been conducted with TPnB-highers as the
reaction mass contains up to 2 % potassium hydroxide and is therefore
classified for skin and eye irritation.
TPnB-H Glycol Ether was classified as non-corrosive based on the results
from an in vitro model for skin corrosion. Due to residual alkalinity
(potassium hydroxide) and pH >11.5 TPnB-highers are classified for skin
and eye irritation.
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