Reaction mass of 6,6'-(2,2-Propanediyl)bis(3-phenyl-3,4-dihydro-2H-1,3-benzoxazine) and N-({4-[2-(3-phenyl-3,4-dihydro-2H-1,3-benzoxazin-6-yl)propan-2-yl]phenoxy}methyl)aniline

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

This study was conducted between 20 September 2016 and 20 January 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: The study is considered to be a reliability 1 as it has been conducted according to OECD TG 105 using the column elution method and in compliance with GLP.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

27 July 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

EC NO. 440/2008 of 30 May 2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Key result

Water solubility:

ca. 0.33 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

0.326 mg/L

Incubation duration:

> 2 h

Temp.:

20 °C

pH:

> 6.3 - < 7.8

Details on results:

Preliminary test:
The preliminary estimate of water solublity was <0.26 mg/L at 20”C.

Definitive test:

The mean peak heights relating to the standard and sample solutions are shown in table below.

Solution	Mean Peak Area x 10^5
Standard 0.162 mg/L	1.6808
Standard 0.158 mg/L	1.3417
Blank Solution	None detected
System A 1A	1.4407
System A 1B	1.4129
System B 1A	0.84288
System B 1B	0.0571
System A 2A	1.2300
System A 2B	1.2268
System B 2A	1.2745
System B 2B	1.2444
Standard 0.152 mg/L	1.3339
Standard 0.152 mg/L	1.4016
Blank Solution	None detected
System A 3A	1.1150
System A 3B	1.3159
System B 3A	1.1362
System B 3B	1.8198
Standard 0.151 mg/L	1.5176
Standard 0.152 mg/L	1.3980
Blank Solution	None detected
System A 4A	2.3858
System A 4B	1.9389
System B 4A	2.1302
System B 4B	2.2788
Standard 0.155 mg/L	1.5578
Standard 0.187 mg/L	1.5010
Blank Solution	None detected
System A 5A	2.0245
System A 5B	1.8095
System B 5A	1.5900
System B 5B	1.8940
Standard 0.151 mg/L	1.2536
Standard 0.154 mg/L	1.6505
System A 6A	1.0576
System A 6B	1.3583
System B 6A	1.3631
System B 6B	2.0155

The concentration (g/l) of test material in the sample solutions is shown in the table below.

Sample number	Sampling Time (hour)		Concentration (g/L x 10^-4)		Solution pH
	System A	System B	System A	System B	System A	System B
1	112.25	112.25	3.03	2.02	6.9	6.3
2	119.25	119.25	2.61	2.68	6.5	6.8
3	136.25	136.25	2.70	328	7.8	6.8
4	160.25	160.25	4.49	4.58	6.3	6.7
5	184.28	184.25	4.02	3.61	6.4	6.6
6	208.25	208.25	2.54	3.56	6.3	6.7

Conclusions:

The water solubility of the test item l was determined to be 0.33 mg/L @ 20 ± 0.5 °C using OECD TG 105 (Water solubility) using the column elution method in compliance with GLP.

Executive summary:

The water solubility of the test item was determined to be 0.33 mg/L @ 20 °C using OECD TG 105 and according to GLP, using the column elution method.

Description of key information

The water solubility of the test item l was determined to be 0.33 mg/L @ 20 ± 0.5 °C using OECD TG 105 (Water solubility) using the column elution method in compliance with GLP.

Key value for chemical safety assessment

Water solubility:

0.33 mg/L

at the temperature of:

20 °C