Registration Dossier
Registration Dossier
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EC number: 229-539-1 | CAS number: 6598-63-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- IUCLID DATASET of CAS 497–19–8
- Author:
- EUROPEAN COMMISSION – European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- IUCLID DATASET, EUROPEAN COMMISSION – European Chemicals Bureau, 18–FEB–2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity study of Sodium carbonate (497–19–8) was performed in mouse.
- GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- no
Test material
- Reference substance name:
- Disodium carbonate
- Cas Number:
- 497-19-8
- Molecular formula:
- CH2O32Na
- IUPAC Name:
- Disodium carbonate
- Details on test material:
- - Name of test material (IUPAC name): Carbonic acid disodium salt
- Common name: Sodium carbonate
- Molecular formula: CH2O3.2Na
- Molecular weight: 105.988 g/mol
- Smiles notation: C(=O)([O-])[O-].[Na+].[Na+]
- InChl: 1S/CH2O3.2Na/c2-1(3)4;;/h(H2,2,3,4);;/q;2*+1/p-2
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Sodium carbonate
- Molecular formula :CH2O3.2Na
- Molecular weight :105.988 g/mole
- Substance type:Organic
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- other: dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 2210 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 210 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% Mortality was observed in treated mouse at 2210 mg/kg bw
- Mortality:
- 50% Mortality was observed in treated mouse at 2210 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 value was considered to be 2210 mg/kg bw,when mice were treated with Sodium carbonate (497–19–8) by dermal application.
- Executive summary:
In acute dermal toxicity study,mice were treated with Sodium carbonate(497–19–8)in the concentration of 2210 mg/kg bw by dermal application.50% mortality was observed in treated mice at dose 2210 mg/kg bw.Therefore, LD50 value was considered to be 2210 mg/kg bw,when mice were treated with Sodium carbonate(497–19–8) by dermal application.
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