Registration Dossier
Registration Dossier
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EC number: 440-740-5 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 MAR 2000 - 27 MAR 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- EG-guideline 92/69/EEC A.6.
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Water solubility:
- 0.125 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 6.6
- Conclusions:
- The water solubility of the test item at 20 °C is 0.125 mg/L.
- Executive summary:
The water solubility of the test item was tested according to EG-guideline 92/69/EEC A.6. in a GLP study at 20°C. The water solubility at this temperature is 0.125 mg/L.
Reference
Preliminary Estimation of the Water Solubility
Even in a total volume of 1000 mL undissolved particles could be observed. Thus the water solubility of the test substance is less than 10 mg/L and had to be determined using the "column elution" method.
Column elution method
The coating check was successful.
According to the guideline, the data of the fractions 1 to 17 were not taken into account for the following evaluation. The following values for the water solubility were calculated from the fractions 18 to 57 for both columns.
Result run 1 : Evaluation of the fractions 18 to 57. The average water solubility was found to be 0.1195 mg/L.
Result run 2: Evaluation of the fractions 18 to 57. The average water solubility was found to 0.131 mg/L.
The recovery rates under the applied conditions were:
Results: recovery rates: 104.5 %, 114.0 %, 103.4 %
Description of key information
The water solubility of the test item was tested according to EG-guideline 92/69/EEC A.6 in a GLP study at 20°C. The water solubility at this temperature is 0.125 mg/L.
Key value for chemical safety assessment
- Water solubility:
- 0.125 mg/L
- at the temperature of:
- 20 °C
Additional information
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