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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02 MAR 2000 - 20 MAR 2000
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose:
reference to same study
Reason / purpose:
reference to same study
Reason / purpose:
reference to same study
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
EG-Guideline 92/69/EEC A.4.
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: vapour pressure balance
Temp.:
25 °C
Vapour pressure:
0 hPa

As a precaution a Differential Scanning Calorimetry was performed. The measurement in a closed glass pan shows an endothermic effect (melting) in the range 110-155 °C, with an onset of 136.6 °C. There was no exothermal effect until 425 °C.

The vapour pressure was measured in the temperature range of 15 to 94 °C. No signal was observed in the range 15 °C up to 38 °C, that means the vapour pressure in this range was below 10-5 hPa. Above this temperature a vapour pressure could be measured.

So the calculation of the vapour pressure curve was restricted on the values between 1.3 x10-4 and 3.0 x10-2 hPa, i.e. between 42.5 °C and 94.2 °C.

The following table shows the measured pressure data at the corresponding temperatures.

Temperature [°C]  Vapour pressure [hPa]
 42.5  1.3 x 10 -4
 47.2  1.6 x 10 -4
 54.2  7.3 x 10 -4
 57.9  1.2 x 10 -3
 62.9  2.5 x 10 -3
 68.4  4.0 x 10 -4

 72.1

 5.1 x 10 -3
 78.4  8.5 x 10 -3
 82.9  1.1 x 10 -2
 89.2  1.8 x 10 -2
 94.2  3.0 x 10 -2

The figure (attached as background material) gives the logarithm of vapour pressure as a function of the inverse temperature (1/T, T in Kelvin).

Only for better readability the temperature is reported in centigrade scale.

The values for 20, 25 and 50 °C are calculated, using the Antoine constants A, B and C as shown there.

 T [°C]  p [hPa]  p [Pa]
 20  7.80 x 10 -6  7.80 x 10 -4
 25  1.57 x 10 -5  1.57 x 10 -3
 505  3.81 x 10 -4  3.81 x 10 -2
Conclusions:
The vapour pressure of the test item is calculated by extrapolation:
20 °C: 0.0000078 hPa
25 °C: 0.0000157 hPa
50 °C: 0.000381 hPa
Executive summary:

The vapour pressure of the sample was tested according to EG-Guideline 92/69/EEC A.4. in a GLP study with the effusion method.

The vapour pressure of the test item is calculated by extrapolation:

20 °C: 0.0000078 hPa

25 °C: 0.0000157 hPa

50 °C: 0.000381 hPa

Description of key information

The vapour pressure of the sample was tested according to Guideline 92/69/EEC A.4.in a GLP study with the effusion method.

The vapour pressure of the test item is calculated by extrapolation:

20 °C: 0.0000078 hPa

25 °C: 0.0000157 hPa

50 °C: 0.000381 hPa

Key value for chemical safety assessment

Vapour pressure:
0 hPa
at the temperature of:
25 °C

Additional information

The values for 20°C, 25°C and 50 °C are calculated, using the Antoine constants.