Registration Dossier
Registration Dossier
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EC number: 248-895-9 | CAS number: 28198-05-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from safety assessment report
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Robust Summary & Test Plans: 4-(1-methyl-1-phenylethyl)-N-[4-(1-methyl-1 phenylethyl)phenyl]aniline: Robust Summary
- Author:
- IUCLID Data Set
- Year:
- 2 003
- Bibliographic source:
- Robust Summary & Test Plans: 4-(1-methyl-1-phenylethyl)-N-[4-(1-methyl-1 phenylethyl)phenyl]aniline: Robust Summary; IUCLID Data Set; 2003 September 3.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- An eye irritation study of 4,4'-DI(DIMETHYLBENZYL)DIPHENYLAMINE (CAS No: 10081-67-1) was conducted on six albino rabbits to observe its irritation efficacy.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-(1-methyl-1-phenylethyl)-N-[4-(1-methyl-1-phenylethyl)phenyl]aniline
- EC Number:
- 233-215-5
- EC Name:
- 4-(1-methyl-1-phenylethyl)-N-[4-(1-methyl-1-phenylethyl)phenyl]aniline
- Cas Number:
- 10081-67-1
- Molecular formula:
- C30H31N
- IUPAC Name:
- 4-(1-methyl-1-phenylethyl)-N-[4-(1-methyl-1-phenylethyl)phenyl]aniline
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): 4-(1-methyl-1-phenylethyl)-N-[4-(1-methyl-1-phenylethyl)phenyl]aniline
- Molecular formula: C30H31N
- Molecular weight: 405.582 g/mol
- Substance type: organic
- Physical state: solid
- InChI: 1S/C30H31N/c1-29(2,23-11-7-5-8-12-23)25-15-19-27(20-16-25)31-28-21-17-26(18-22-28)30(3,4)24-13-9-6-10-14-24/h5-22,31H,1-4H3
-Smiles: N(c1ccc(cc1)C(c1ccccc1)(C)C)c1ccc(cc1)C(c1ccccc1)(C)C
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 4-(1-methyl-1-phenylethyl)-N-[4-(1-methyl-1-phenylethyl)phenyl]aniline
- Molecular formula: C30H31N
- Molecular weight: 405.582 g/mol
- Substance type: organic
- Physical state: solid
- InChI: 1S/C30H31N/c1-29(2,23-11-7-5-8-12-23)25-15-19-27(20-16-25)31-28-21-17-26(18-22-28)30(3,4)24-13-9-6-10-14-24/h5-22,31H,1-4H3
-Smiles: N(c1ccc(cc1)C(c1ccccc1)(C)C)c1ccc(cc1)C(c1ccccc1)(C)C
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
Test system
- Vehicle:
- not specified
- Controls:
- yes
- Amount / concentration applied:
- 3mg
- Duration of treatment / exposure:
- 72 hours
- Observation period (in vivo):
- 24, 48 and 72 hours
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- - Area of exposure: The right eye
- SCORING SYSTEM: Draize method.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 110
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- All rabbits showed normal appearance throughout the study and there was no evidence of systemic toxicity from mucous membrane absorption. No gross signs of eye irritation were observed at any observation interval following application of chemical to the eyes of albino rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The test material 4,4'-DI(DIMETHYLBENZYL)DIPHENYLAMINE (CAS No: 10081-67-1) was considered to be not irritating to the eyes of albino rabbits.
- Executive summary:
An eye irritation study of 4,4'-DI(DIMETHYLBENZYL)DIPHENYLAMINE (CAS No: 10081-67-1) was conducted on six albino rabbits to observe its irritation efficacy.
In this study, 3 mg of the test chemical was applied to the right eye of each of six albino rabbits. The left eye was untreated and served as a control. Each rabbit was examined for eye irritative effects and for gross signs of systemic toxicity at intervals of 24, 48 and 72 hours after application.
It was observed that, all rabbits had normal appearance throughout the study and there was no evidence of systemic toxicity from mucous membrane absorption. No gross signs of eye irritation were observed at any observation interval following application of chemical to the eyes of albino rabbits.
Since no signs of irritation were observed at any observation point, the chemical4,4'-DI(DIMETHYLBENZYL)DIPHENYLAMINE (CAS No: 10081-67-1)was considered to be not irritating to the eyes ofalbinorabbits.
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