Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Remarks:
similiar to EU method A.8
Cross-reference
Reason / purpose:
reference to same study
Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
according to OECD
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Type of method:
flask method
Water solubility:
> 575 g/L
Temp.:
30 °C
pH:
8.5

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
EU Method A.8 (Partition Coefficient)
Principles of method if other than guideline:
Based on the determined solubilities in water and in n-octanol the partition coefficient was calculated
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
-5.981
Temp.:
25 °C
pH:
ca. 8.5

Any other information on results incl. tables

Solubility of M-377 in n-octanol: 0.6 mg/L

Water solubility of M-377: 575 g/L

Pow M-377 = 1.04 x 10 -6

log Pow M-377 = - 5.981

Applicant's summary and conclusion