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EC number: 680-798-0 | CAS number: 886577-76-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 - 24 Nov 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Staatliches Gewerbeaufsichtsamt Hildesheim
Test material
- Reference substance name:
- 2-isocyanato-2-methyl-3-(prop-2-enoyloxy)propyl prop-2-enoate
- Cas Number:
- 886577-76-0
- Molecular formula:
- C11H13NO5
- IUPAC Name:
- 2-isocyanato-2-methyl-3-(prop-2-enoyloxy)propyl prop-2-enoate
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- TOC
- Details on sampling:
- - Concentrations: all test item concentrations and the control were analytical verified- Sampling method: according to DIN EN 1484 in fresh media at the start of the exposure and at renewal (0 and 24 h) and in 24-h old media at renewal and at the end of the test (24 and 48 h)
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)- Method: 20 g test solution per replicate were weighed out into each test vessel. This corresponds to 20 mL per test vessel. Test solution was renewed after 24 h. Daphnids were transferred by pipette into freshly prepared test solutions.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM - Common name: water flea - Strain/clone: Daphnia magna STRAUS (Clone 5) - Source: Niedersachsischer Landesbetrieb für Wasserwirtschaft, Kosten- und Naturschutz, Ander Scharlake 39, 31135 Hildesheim, Germany - Feeding during test: no - Food type: for culture daphnids with a mix of unicellular green algae with a cell density of >10 E+06 cells/mL. - Frequency: at least 5 times per week ACCLIMATION: Acclimatization was not necessary, because the dilution water was equivalent to the culture medium. METHOD FOR PREPARATION AND COLLECTION OF EARLY INSTARS OR OTHER LIFE STAGES: Less than 24 h old daphnids from a healthy stock were used for the study. Juvenile daphnids were removed from the culture vessels at the latest 24 h before the start of the exposure and discarded. The juveniles born within the following period of max. 24 h preceding the exposure were used for the test. No first brood progeny was used for the test.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 171 - 180 mg CaCO3/L
- Test temperature:
- 18 - 19 °C
- pH:
- 7.51 - 8.05 (Control)7.43 - 8.15 (test item concentrations)
- Dissolved oxygen:
- 8.75 - 8.87 mg/L (control)8.72 - 8.93 mg/L (test item concentration)
- Conductivity:
- 441 - 472 µS/cm
- Nominal and measured concentrations:
- Control, 6.25, 12.5, 25.0, 50.0 and 100 mg/L (nominal)
- Details on test conditions:
- TEST SYSTEM Test vessel: - Type: open (loosely covered with watch glasses) - Material, size, headspace, fill volume: Glass beakers (4 (ID) x 7 (H) cm), 50 mL capacity, Test volume: 20 mL - Aeration: None - Renewal rate of test solution: every 24 h - No. of organisms per vessel: 5 - No. of vessels per concentration (replicates): 4 - No. of vessels per control (replicates): 4 TEST MEDIUM / WATER PARAMETERS - Source/preparation of dilution water: Composition of the Culture Medium Elendt M4 according to OECD 202, Annex 3 (2004). Modifications: to a total hardness of approximately 160 to 180 mg CaC03/L - Culture medium different from test medium: Same as culture medium - Intervals of water quality measurement: Prior to the start of the exposure (0 h) and the water renewal (24 h), the water quality parameters (i.e. pH-value, dissolved oxygen concentration, temperature, conductivity and total hardness) of the dilution water were measured OTHER TEST CONDITIONS - Photoperiod: 16/8 h light/dark cycle - Light intensity: Diffuse light, light intensity of max. 1500 Iux EFFECT PARAMETERS MEASURED: Mobility RANGE-FINDING STUDY: non-GLP - Test concentrations: Control, 1, 10 and 100 mg/L - Results used to determine the conditions for the definitive study: Based on the results of the non-GLP range-finding the main test was performed.
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 29.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% confidence limits: 25.1 - 45.5 mg/L
- Details on results:
- - Mortality of control: no immobility in the control - Others: Biological and analytical results are summarized with the Tables 1-2 in the section "Any other information on results incl. tables"
- Results with reference substance (positive control):
- - EC50: 0.802 mg/L
Any other information on results incl. tables
Table 1: Immobilization Rates after 24 and 48 hours of Exposure during the Definitive Test
Nominal test item concentration [mg/L] | IMMOBILIZATION [%] | |||||||||
24 hours |
| 48 hours | ||||||||
Replicates |
| Replicates | ||||||||
1 | 2 | 3 | 4 | Mean | 1 | 2 | 3 | 4 | Mean | |
100 | 100 | 100 | 100 | 100 | 100 | 100% mortality after 24 hours | ||||
50.0 | 100 | 100 | 100 | 100 | 100 | 100% mortality after 24 hours | ||||
25.0 | 0 | 0 | 0 | 0 | 0 | 0 | 20 | 0 | 0 | 5 |
12.5 | 0 | 0 | 0 | 0 | 0 | 20 | 0 | 0 | 0 | 5 |
6.25 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Control | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Table 2: Measured TOC Concentrations during the Definitive Test
Sampling date | 2016-11-22 Start of the exposure interval 0 hours | 2016-11-23 End of the exposure interval 24 hours | 2016-11-23 Start of the exposure interval 24 hours | 2016-11-24 End of the exposure interval 48 hours |
Start of analysis | 2016-11-22 | 2016-11-23 | 2016-11-23 | 2016-11-24 |
Nominal test item concentration [mg/L] | Total Organic Carbon (TOC) | |||
Measured concentration 1) [mg/L] | Measured concentration 1) [mg/L] | Measured concentration 1) [mg/L] | Measured concentration 1) [mg/L] | |
100 | 52.6 | 53.1 | Not determined, due to 100% mortality after 24 hours | |
50.0 | 27.1 | 27.6 | ||
25.0 | 14.9 | 14.9 | 15.5 | 17.3 |
12.5 | 8.34 | 8.16 | 9.21 | 9.30 |
6.25 | 5.43 | 5.34 | 6.25 | 6.51 |
Control | 2.49 | 2.35 | 2.21 | 2.12 |
1) = measured TOC concentration, mean value of 2 injections The limit of quantification of the analytical method is set to 2.00 mg/L.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
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