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Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
ASSESSMENT OF THE ACUTE TOXICITY AND POTENTIAL IRRITANCY OF HAIR DYE CONSTITUENTS
Author:
G. K. LLOYO, M. P. LIGGETT, S. R. KYNOCH and R. E. DAVIES
Year:
1977
Bibliographic source:
Food and Cosmetics Toxicology Vol. 15, pp. 607-610. Pergamon Press 1977.
Reference Type:
review article or handbook
Title:
Resorcinol
Author:
World Health Organization (WHO).
Year:
2006
Bibliographic source:
The United Nations Environment Programme (UNEP); International Programme on Chemical Safety (IPCS); 2006

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: According to the United States Code of Federal Regulations (Federal Hazardous Substances Act Regulations 16: Section 1500.41, Method of testing primary irritant substances).
Principles of method if other than guideline:
The skin irritation study of Resorcinol (CAS No: 108-46-3) was conducted on intact and abraded skin of three New Zealand White rabbits according to the United States Code of Federal Regulations (Federal Hazardous Substances Act Regulations 16: Section 1500.41, Method of testing primary irritant substances).
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3 benzenediol
Cas Number:
108-46-3
Molecular formula:
C6H6O2
IUPAC Name:
1,3 benzenediol
Test material form:
solid
Details on test material:
- Name of test material (as cited in study report): Resorcinol
- Molecular formula: C6H6O2
- Molecular weight: 110.1114 g/mol
- Substance type: organic
- Physical state: solid
-Smiles: c1c(cccc1O)O
-InChI: 1S/C6H6O2/c7-5-2-1-3-6(8)4-5/h1-4,7-8H
Specific details on test material used for the study:
- Name of test material (as cited in study report): Resorcinol
- Molecular formula: C6H6O2
- Molecular weight: 110.1114 g/mol
- Substance type: organic
- Physical state: solid
-Smiles: c1c(cccc1O)O
-InChI: 1S/C6H6O2/c7-5-2-1-3-6(8)4-5/h1-4,7-8H

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
not specified
Preparation of test site:
other: intact and abraded skin
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
2.5%
Duration of treatment / exposure:
72 Hours
Observation period:
72 Hours
Number of animals:
3 rabbits
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
72 h
Score:
0
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No cutaneous reactions were observed during the observation period.

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The test material Resorcinol (CAS No: 108-46-3) was considered to be not irritating to intact and abraded skin of three New Zealand White rabbits.
Executive summary:

The skin irritation study of Resorcinol (CAS No: 108-46-3) was conducted on intact and abraded skin of three New Zealand White rabbits according to the United States Code of Federal Regulations (Federal Hazardous Substances Act Regulations 16: Section 1500.41, Method of testing primary irritant substances).

 

The test involved the dermal application of a 2.5% (w/v) solution of resorcinol to intact or abraded skin and the dermal reactions were evaluated over period of 72 hours.

 

The chemical caused no dermal effects with primary irritation index of 0.0.Therefore the chemical Resorcinol (CAS No: 108-46-3) wasconsidered to be not irritating to rabbits’ skin.