Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 287-337-9 | CAS number: 85480-57-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 080 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Oral:
A study was conducted to determine the acute oral toxicity of the read-across substance, benzenesulfonic acid, C10-13-alkyl derivs., sodium salts, according to OECD Guideline 401. The test substance was administered to male and female rats by oral gavage at doses of 0, 1075, 1220, 1360 or 1710 mg/kg bw (active ingredient). Animals were observed for 14 d after dosing. Body weights were measured on Days 7 and 14. Necropsies were performed at the end of the study. Almost all animals died at doses of 1220 mg/kg bw and above. Symptoms beginning about 30 min post administration included diarrhea, squatting, breathing difficulties, nose bleeding, ataxia, and lethargy. These symptoms disappeared in surviving animals by 120 h. No effects on body weight were seen. In the animals that died before the end of the study, red mucous was seen in the stomach and intestine. In the surviving animals, hyperemia of the stomach was noted, along with abnormalities of the stomach, liver, spleen, kidneys, and the peritoneum. Under the study conditions, the acute oral LD50 of the substance was determined to be 1080 mg/kg bw in rats (Murmann, 1984).
Justification for classification or non-classification
Based on the results of an acute oral toxicity study with the read-across substance, benzenesulfonic acid, C10-13-alkyl derivs., sodium salts
in the rat, the substance warrants Acute Tox 4 - H302 (Harmful if swallowed) classification according to EU CLP (EC) 1272/2008 criteria.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
