Registration Dossier
Registration Dossier
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EC number: 238-098-4 | CAS number: 14228-73-0
Endpoint summary
Administrative data
Description of key information
Additional information
Acute aquatic toxicity data are available for 3 trophic levels: an alga, an aquatic invertebrate (daphnia), and a fish (rainbow trout). These studies were all conducted based on the GLP and OECD guidelines. The LC50 and EC50 values in all studies are the following:
1)
Fish (Rainbow trout):
The 24-hour LC50 = 17.5 mg/L (95% confidence interval 13.4 – 22.8 mg/L)
The 48-hour LC50 = 10.1 mg/L (95% confidence interval unreliable)
The 72-hour LC50 = 10.1 mg/L (95% confidence interval unreliable)
The 96-hour LC50 = 10.1 mg/L (95% confidence interval unreliable)
The 96-hour NOEC = 3.38 mg/L (Based on the highest concentration
exhibiting no significant mortality or sublethal effects)
2)
Daphnia:
The 24-hour EC50 = 42.1 mg/L (95% confidence limits not calculable)
The 48-hour EC50 = 16.3 mg/L ( 95% confidence limits 14.4 – 18.3 mg/L)
The 48-hour NOEC = 11.7 mg/L
3)
Aquatic Alga:
The 72-hour cell density EC50 = 9.99 mg/L
The 72-hour cell yield EyC50 = 10.5 mg/L
The 72-hour cell growth inhibition ErC50 =26.7 mg/L
The 72 -hour NOEC 25 mg/L, respectively.
Beside those acute studies discussed above, a GLP and OECD guideline long-term (21-day) aquatic invertebrates (Daphnia) was also conducted and rthe chronic toxicity values are the following:
The LOEC and MATC for survival, reproduction, and length and weight (at study termination) were >11.7 mg/L.
The NOEC for survival, reproduction, and length and weight (at study termination) was 11.7 mg/L.
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