Registration Dossier
Registration Dossier
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EC number: 200-090-3 | CAS number: 51-34-3
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the physicochemical properties of the substance indicate that it can be expected to have a low potential for adsorption
- Justification for type of information:
- Scopolamine, is a tertiary amine having a pKa of 7.75 and therefore a medium-strong, organic base. This means that the substance is present predominately as cation in the environmental relevant range pH 6 to pH 8. Scopolamine has a low octanol-water partition coefficient (Log Kow 1.31) and is very soluble in water (29.82 g/L at 20°C). Using the Log Kow of 1.31, a adsorption coefficient of Log Koc 1.288 was calculated. Based on these physico-chemical properties, and with the substance is considered to be inherently biodegradable, fulfilling specific criteria, Scopolamine when released in the environment is expected to mainly partition in water phase. This is also supported by its predicted log Koc of 1.288 indicating that Scopolamine is mobile in soil. Thus, no further testing is considered necessary.
Reference
Description of key information
The study does not need to be conducted because the substance has a low octanol water partition coefficient (Log Kow 1.31 at 20°C and pH 9), is very soluble in water (29.82 g/L at 20°C) and is inherently biodegradable, fulfilling specific criteria. Based on the data available, no further testing is considered necessary. However, for PNEC calculation a Koc of 19.4 was calculated according to Di Toro, 1985 ( A particle interaction model of reversible organic chemical sorption; Chemosphere 14(10):1503-1538).
Calculation formula: Adsorption coefficient per organic carbon (Koc): log Koc = 0.00028 + (0.983 x log Kow).
Key value for chemical safety assessment
- Koc at 20 °C:
- 19.4
Additional information
[LogKoc: 1.288]
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