Registration Dossier
Registration Dossier
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EC number: 618-043-4 | CAS number: 876666-07-8
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Insufficient documentation for an assessment of reliability.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2H-1-Benzopyran-2-methanol, alpha,alpha'-[[(phenylmethyl)imino]bis(methylene)]bis[6-fluoro-3,4-dihydro-, (alphaR,alpha'R,2R,2'S)-rel-
- EC Number:
- 618-043-4
- Cas Number:
- 876666-07-8
- Molecular formula:
- C29H31F2NO4
- IUPAC Name:
- 2H-1-Benzopyran-2-methanol, alpha,alpha'-[[(phenylmethyl)imino]bis(methylene)]bis[6-fluoro-3,4-dihydro-, (alphaR,alpha'R,2R,2'S)-rel-
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): JNJ-17303806-AAA (T001586)
- Physical state: solid, powder
- Appearance: white, beige
Constituent 1
Results and discussion
Solubility in organic solvents / fat solubilityopen allclose all
- Medium:
- methanol
- Solubility:
- 1.1 other: g/100 mL solution
- Medium:
- ethanol
- Solubility:
- 0.69 other: g/100 mL solution
- Medium:
- isopropanol
- Solubility:
- 0.26 other: g/100 mL solution
- Medium:
- other: dichloromethane
- Solubility:
- 23 other: g/100 mL solution
- Medium:
- other: 2-propanone
- Solubility:
- 7.5 other: g/100 mL solution
- Medium:
- ethyl acetate
- Solubility:
- 6.1 other: g/100 mL solution
- Medium:
- other: 1,1'-oxybisethane
- Solubility:
- 0.75 other: g/100 mL solution
- Medium:
- other: methylbenzene
- Solubility:
- 2.1 other: g/100 mL solution
- Medium:
- other: 4-methyl-2-pentanone
- Solubility:
- 3.9 other: g/100 mL solution
- Medium:
- other: 2-butanone
- Solubility:
- 11 other: g/100 mL solution
- Details on results:
- no data
Any other information on results incl. tables
Table 1 Solubility of the T001586 at room temperature
| Solvent | Concentration in g/100 mL solution |
| tetrahydrofuran | > 30 |
| 2,2'-oxybispropane | 0.14 |
| N,N-dimethylacetamide | > 30 |
| N,N-dimethylformamide | > 30 |
| sulfinylbismethane | > 30 |
| hexane | 0.006 |
Applicant's summary and conclusion
- Executive summary:
Not applicable
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