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EC number: 600-337-9 | CAS number: 102691-36-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From June 20th 2018 to August 25th 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- 2004
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- 2008
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-({bis[bis(propan-2-yl)amino]phosphanyl}oxy)propanenitrile
- EC Number:
- 600-337-9
- Cas Number:
- 102691-36-1
- Molecular formula:
- C15H32N3OP
- IUPAC Name:
- 3-({bis[bis(propan-2-yl)amino]phosphanyl}oxy)propanenitrile
- Test material form:
- liquid
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
Duration of testopen allclose all
- Duration:
- 1.5 h
- pH:
- 4
- Temp.:
- 20 °C
- Initial conc. measured:
- 16.2 mg/L
- Duration:
- 213 h
- pH:
- 7
- Temp.:
- 20 °C
- Initial conc. measured:
- 19.5 mg/L
- Duration:
- 7 h
- pH:
- 9
- Temp.:
- 20
- Initial conc. measured:
- 19.5 mg/L
- Duration:
- 21 h
- pH:
- 7
- Temp.:
- 20 °C
- Initial conc. measured:
- 20 mg/L
- Remarks:
- undr non GLP conditions, the pH 7 Buffer for environmental testing was also assessed ( used for Daphnia studies)
- Number of replicates:
- 2
Results and discussion
- Transformation products:
- yes
- Remarks:
- identification performed in a dedicated study under non GLP conditions
Identity of transformation productsopen allclose all
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- N-isopropylpropan-2-amine
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 203-558-5]
- CAS number:
- 108-18-9
- Identity:
- 2-Propanamine, N-(1-methylethyl)-
- Molecular formula:
- C6H15N
- Molecular weight:
- 101.19
- SMILES notation:
- CC(C)NC(C)C
- InChl:
- InChI=1/C6H15N/c1-5(2)7-6(3)4/h5-7H,1-4H3
- No.:
- #2
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- 3-hydroxypropanenitrile
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 203-704-8]
- CAS number:
- 109-78-4
- Identity:
- Hydracrylonitrile
- Identity:
- Propanenitrile, 3-hydroxy-
- Molecular formula:
- C3H5NO
- Molecular weight:
- 71.078
- SMILES notation:
- OCCC#N
- InChl:
- InChI=1/C3H5NO/c4-2-1-3-5/h5H,1,3H2
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 1.396 h-1
- DT50:
- 0.497 h
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.009 h-1
- DT50:
- 75.7 h
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.222 h-1
- DT50:
- 3.12 h
- Details on results:
- Additional information povided for reconstituted water at pH 7 and the determination of the hydrolysed products was performed, allowing the identification of the two substances diisopropylamine and 3 hydroxypropanenitrile.
Using reconstituted water at pH 7 and after 21 hours, 85.7% of degradation of the test item was observed. The DT50 was estimated under these conditions to be about 9.1 hours
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The objective of this study was to define the degradation of 2-CYANOETHYL N,N,N’,N’ TETRAISOPROPYLPHOSPHORODIAMIDITE (commercial name) during a pH dependent hydrolysis.
The results of the abiotic degradation are summarised as following:
At pH 4, the rate constant is equal to 1.396 hour –1 and the half-life period is equal to 0.497 hours at 25.0 °C.
At pH 7, the rate constant is equal to 0.009156 hour –1 and the half-life period is equal to 75.7 hours at 25.0 °C.
At pH 9, the rate constant is equal to 0.2223 hour –1 and the half-life period is equal to 3.12 hours at 25.0 °C.
A complementary non GLP analyses with two different preparations were performed during 21 hours to complete the abiotic degradation at pH 7.
The results are summarised as following:
Using buffer pH 7 solvent at pH 7 and after 21 hours, 16% of degradation of the test item was observed.
Using reconstituted water at pH 7 and after 21 hours, 85.7% of degradation of the test item was observed. - Executive summary:
The objective of this study was to define the degradation of 2-CYANOETHYL N,N,N’,N’ TETRAISOPROPYLPHOSPHORODIAMIDITE (commercial name) during a pH dependent hydrolysis.
The results of the abiotic degradation are summarised as following:
At pH 4, the rate constant is equal to 1.396 hour –1 and the half-life period is equal to 0.497 hours at 25.0 °C.
At pH 7, the rate constant is equal to 0.009156 hour –1 and the half-life period is equal to 75.7 hours at 25.0 °C.
At pH 9, the rate constant is equal to 0.2223 hour –1 and the half-life period is equal to 3.12 hours at 25.0 °C.
A complementary non GLP analyses with two different preparations were performed during 21 hours to complete the abiotic degradation at pH 7.
The results are summarised as following:
Using buffer pH 7 solvent at pH 7 and after 21 hours, 16% of degradation of the test item was observed.
Using reconstituted water at pH 7 and after 21 hours, 85.7% of degradation of the test item was observed.
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