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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from autheritative database.

Data source

Reference
Reference Type:
other: autheritative database
Title:
Acute oral toxicity study for CAS no: 17804-49-8
Author:
U.S .National library of medicine
Year:
2017
Bibliographic source:
ChemIDplus A TOXNET DATABASE.2017

Materials and methods

Principles of method if other than guideline:
Acute oral toxicity study of Disodium 5-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonate (CAS no.: 17804-49-8) in rats.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report):disodium 5-[(dichloro-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-[(E)-2-phenyldiazen-1-yl]naphthalene-2,7-disulfonate
- Molecular formula :C19H10Cl2N6Na2O7S2
- Molecular weight :615.35g/mole
- Substance type:Organic
- Physical state:No data available
- Purity:No data available
- Impurities (identity and concentrations):No data available
Specific details on test material used for the study:
- Name of test material (as cited in study report):disodium 5-[(dichloro-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-[(E)-2-phenyldiazen-1-yl]naphth alene-2,7-disulfonate
- Molecular formula :C19H10Cl2N6Na2O7S2
- Molecular weight :615.35g/mole
- Substance type:Organic
- Physical state:No data available
- Purity:No data available
- Impurities (identity and concentrations):No data available

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
7460 mg/kg
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
7 460 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be 7460.0 mg/kg body weight, when rats were treated with Disodium 5-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonate (CAS no.: 17804-49-8) via oral route.
Executive summary:

Acute oral toxicity study was conducted in rats using Disodium 5-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonate (CAS no.: 17804-49-8) in rats. 50% mortality was observed at dose 7460mg/kg bw. Hence LD50 was considered to be 7460mg/kg body weight, when rats were treated Disodium 5-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonate via oral route.