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EC number: 201-989-3 | CAS number: 90-40-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from handbooks and RTECS
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Eye irritation of 2-aminonaphthalene-1,5-disulfonic acid
- Author:
- Richard J Lewis, Sr
- Year:
- 2 012
- Bibliographic source:
- SAX's Dangerous properties of industrial material, 12th edition, 2012
- Reference Type:
- secondary source
- Title:
- RTECS - QJ6135000, review date – January, 1997
- Author:
- RTECS®
- Year:
- 1 997
- Bibliographic source:
- RTECS - QJ6135000, RTECS®, review date – January, 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the eye irritation potential of 2-aminonaphthalene-1,5-disulfonic acid in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-aminonaphthalene-1,5-disulphonic acid
- EC Number:
- 204-201-6
- EC Name:
- 2-aminonaphthalene-1,5-disulphonic acid
- Cas Number:
- 117-62-4
- Molecular formula:
- C10H9NO6S2
- IUPAC Name:
- 2-aminonaphthalene-1,5-disulfonic acid
- Test material form:
- solid
- Details on test material:
- - Name of test material :2-aminonaphthalene-1,5-disulfonic acid
- Molecular formula : C10H9NO6S2
- Molecular weight : 303.314 g/mol
- Smiles notation : c12c(c(ccc2)S(O)(=O)=O)ccc(c1S(O)(=O)=O)N
- InChl : 1S/C10H9NO6S2/c11-8-5-4-6-7(10(8)19(15,16)17)2-1-3-9(6)18(12,13)14/h1-5H,11H2,(H,12,13,14)(H,15,16,17)
- Substance type:Organic
- Physical state:Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 2-aminonaphthalene-1,5-disulfonic acid
- Molecular formula: C10H9NO6S2
- Molecular weight: 303.314 g/mol
- Smiles notation: c12c(c(ccc2)S(O)(=O)=O)ccc(c1S(O)(=O)=O)N
- InChl: 1S/C10H9NO6S2/c11-8-5-4-6-7(10(8)19(15,16)17)2-1-3-9(6)18(12,13)14/h1-5H,11H2,(H,12,13,14)(H,15,16,17)
- Substance type: Organic
- Physical state: Solid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 20mg
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 24 hours
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- no data available
- Details on study design:
- no data available
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritant / corrosive response data:
- Moderate irritation observed
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- 20 mg of 2-aminonaphthalene-1,5-disulfonic acid caused moderate irritation to the rabbit eyes after 24 hours.
Hence, 2-aminonaphthalene-1,5-disulfonic acid can be considered moderately irritating rabbit eyes. - Executive summary:
The eye irritation potential of 2-aminonaphthalene-1,5-disulfonic acid was assessed in rabbits.20 mg of 2-aminonaphthalene-1,5-disulfonic acid was instilled into the eyes of rabbits. The rabbits were observed for signs of ocular lesions till 24 hours.
20 mg of 2-aminonaphthalene-1,5-disulfonic acid caused moderate irritation to the rabbit eyes after 24 hours.
Hence, 2-aminonaphthalene-1,5-disulfonic acid can be considered moderately irritating rabbit eyes.
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