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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Authorized database

Data source

Reference
Reference Type:
other: Authorized database
Title:
GESTIS for the CAS: 1122-62-9
Author:
IFA (GESTIS)
Year:
2017
Bibliographic source:
GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften); 2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity study of 2-Acetylpyridine n rats
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Reference substance name:
2-Acetylpyridine
Cas Number:
1122-62-9
Molecular formula:
C7H7NO
IUPAC Name:
2-Acetylpyridine
Details on test material:
- Name of test material (as cited in study report): 2-Acetylpyridine
- Molecular formula (if other than submission substance): C7H7NO
- Molecular weight (if other than submission substance): 121.138 g/mole
- Substance type: Organic
- Physical state: solid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-Acetylpyridine
- Molecular formula (if other than submission substance): C7H7NO
- Molecular weight (if other than submission substance): 121.138 g/mole
- Substance type: Organic
- Physical state: solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
2280 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 280 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed
Mortality:
No mortality was observed
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be 2280 mg//kg bw when rats were treated with 2-Acetylpyridine orally.
Executive summary:

In a acute oral toxicity study, rats were treated with 2-Acetylpyridine in the concentration of 2280 mg/kg bw orally. 50 % mortality was observed in treated rats. Therefore, LD50 was considered to be 2280 mg//kg bw when rats were treated with 2-Acetylpyridine orally.