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Environmental fate & pathways

Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24 December 2015 to 08 March 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: study according to the guideline under GLP
Qualifier:
according to
Guideline:
EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
Qualifier:
according to
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
GLP compliance:
yes
Type of method:
HPLC estimation method
Radiolabelling:
no
Details on study design: HPLC method:
- Test solution: 1200 mg/L in 40/60 (v/v) methanol/water (duplicate injection).
- Reference solutions: Acetanilide in 40/60 (v/v) methanol/water

Instrument Alliance Separation Module 2695 (Waters, Milford, MA, USA)
Detector Refractive index detector 2414 (Waters)
Column Hypersil BDS-CN, 150 mm x 4.6 mm i.d., dp = 5 µm (Thermo Fisher Scientific, Waltham, MA, USA)
Column temperature 35°C ± 1°C
Mobile phase 40/60 (v/v) methanol/water
Flow 1 ml/min
Injection volume 10 µl
RI detection Sensitivity 4
Time constant 1 second
Temperature 30°C
Analytical monitoring:
yes
Type:
Koc
Value:
< 18 dimensionless
Type:
log Koc
Value:
< 1.26 dimensionless
Details on results (HPLC method):
The substance is a salt and the pH was kept at 7

Adsorption coefficient of the test substance

Substance

tr,1
[min]

tr,2
[min]

mean tr
(n=2)

log Koc

Koc

 

 

 

 

 

 

Acetanilide

2.417

2.418

 

1.26

 

 

 

 

 

 

 

Test item

1.471

1.470

1.471

< 1.26

< 1.8´101

 

 

 

 

 

 

 

Validity criteria fulfilled:
yes
Conclusions:
The logKoc of the test substance is <1.26
Executive summary:

The HPLC method was used to assess the Koc of the substance. The result was a logKoc of < 1.26.

Description of key information

The HPLC method was used to assess the Koc of the substance. The result was a logKoc of < 1.26.

Both components have a low logKow and the adsorption potential is therefore considered to be limited.

Key value for chemical safety assessment

Koc at 20 °C:
18

Additional information

[LogKoc: 1.26]