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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data is from NTRL reports

Data source

Reference
Reference Type:
secondary source
Title:
Results of range finding toxicological test on x-isopropyl biphenyl with cover letter
Author:
NTRL report
Year:
1984
Bibliographic source:
OTS0206598, NTRL report, Last updated 1984

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the ocular irritation potential of isopropyl biphenyl in rabbits
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Details on test material:
Name of the test chemical:(1-methylethyl)-1,1'-biphenyl
Common Name: Isopropylbiphenyl
Molecular Formula: C15H16
Molecular Weight: 197.299 g/mol
Smiles Notation: c1(c2ccccc2)ccccc1.C(C)(C)
Substance Type: Organic
Physical State: Solid
Specific details on test material used for the study:
Name of the test chemical:(1-methylethyl)-1,1'-biphenyl
Common Name: Isopropylbiphenyl
Molecular Formula: C15H16
Molecular Weight: 197.299 g/mol
Smiles Notation: c1(c2ccccc2)ccccc1.C(C)(C)
Substance Type: Organic
Physical State: Solid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
no data available
Duration of treatment / exposure:
no data available
Observation period (in vivo):
no data available
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: but time not specified

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritation observed

Any other information on results incl. tables

Table: Eye Contact – rabbit

Material

Treatment conditions

Remarks

Undiluted

Unwashed and washed

Not irritating

 

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Undiluted isopropyl biphenyl was essentially not irritating to unwashed and washed eyes of rabbits.
Hence, isopropyl biphenyl can be considered not irritating to eyes.
Executive summary:

The ocular irritation potential of isopropyl biphenyl was assessed in rabbits. Undiluted isopropyl biphenyl was instilled into the eyes of rabbits. Some eyes were washed and some remained unwashed throughout the study (number of animals and duration not mentioned). The treated eyes were observed for signs of irritation.

Undiluted isopropyl biphenyl was essentially not irritating to unwashed and washed eyes of rabbits.

Hence, isopropyl biphenyl can be considered not irritating to eyes.