Oligomeric reaction products of 4,4'-propane-2,2-diyldiphenol and 2-methyloxirane and 2-(chloromethyl)oxirane

Density

Link to relevant study record(s)

Reference

Endpoint:

relative density

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

10 August 2012 - 20 November 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP compliant study conducted in accordance with international guidelines.

Justification for type of information:

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Common functional groups and similar composition.

EP-4000s and the registered substance are very similar. They are UVBC substances and both are oligomeric reaction products of 4,4'-propane-2,2-diyldiphenol and 2-methyloxirane and 2-(chloromethyl)oxirane where constituents are structurally related. EP-4000s contains less than 0.1% monochlorinated constituents while the registered substance contains approximately 10% monochlorinated constituents. As these are otherwise structurally similar to other constituents it can be reasonably expected that EP-4000s and the registered substance will have essentially the same properties.

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)

EP4000s:
Purity 79.7-90%, 3 main components F, E, C
Impurities:
5 known by-products 18%
6 unknown impurities 2.4%
Water 0.1%
Chlorinated impurities <0.1%

Aliphaticdiol diglycidyl ether:
Purity 92.57%, 3 main components F, E, C
Impurities:
5 known by-products (same identity as EP-400s) 14.37%
Water none
Two new impurities (I and J) 10.48% in total

Further details are provided in Section 13 Assessment Reports

3. ANALOGUE APPROACH JUSTIFICATION

Read across all data – the presence of one chlorine atom in components comprising 10% of a relatively high molecular weight mixture will not have a significant effect on physicochemical properties. Furthermore, alky halides are known to have fire retardant properties and therefore impurities I and J will not confer any flammable properties. It is noted that the log Pow is determined on the three main components of EP-4000s which means if the test was repeated on the Aliphaticdiol diglycidyl ether the result would be the same as both substances have the same three main components.

Overall conclusion – no new information would be gained by testing Aliphaticdiol diglycidyl ether for physicochemical properties.

4. DATA MATRIX

Not applicable – read across based on similar composition for all physicochemical endpoints.

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

pycnometer method

Type:

relative density

Density:

1.12

Temp.:

20 °C

Remarks on result:

other: Two tests were performed concurrently using separate pyknometers.

Conclusions:

The relative density was found to be 1.12.

Description of key information

The relative density is 1.12.

Key value for chemical safety assessment

Relative density at 20C:

1.12

Additional information

A relative density determination was conducted as part of a package of physicochemical testing on EP-4000S (Huntingdon Life Sciences, 2012, Study CVJ0131). The study was conducted in compliance with GLP and the relative density determination was performed according to EC and OECD test guidelines.

The relative density of EP-4000S was found to be 1.12.

The value of 1.12 for the relative density of EP-4000s will be taken as the value for the registered substance.

Justification for read across justification - EP-4000s and the registered substance are very similar. They are UVBC subtances and both are oligomeric reaction products of 4,4'-propane-2,2-diyldiphenol and 2-methyloxirane and 2-(chloromethyl)oxirane where consituents are structurally related. EP-4000s contains less than 0.1% monochlorinated consitiuents while the registered substance contains approximately 10% monochlorinated constituents, but as these are otherwise structurally similar to other constituents it can be reasonably expected that EP-4000s and the registered substance will have essentially the same physicochemcial properties.