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Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

The following table illustrates the read across approach taken within the TMP ester group of the polyol esters category. For practicality reasons, only the ecotoxicological parameters for the terrestrial compartment of the relevant substances used as part of a read across approach for the TMP esters of the category have been listed in the table below. A complete data matrix of all polyol esters for terrestrial toxicity is mapped in detailed in the category justification attached in IUCLID section 13 of this dossier.  

Ecotoxicological parameters for the terrestrial toxicity of the TMP ester group

CAS

Toxicity to soil macroorganisms except arthropods

Toxicity to terrestrial arthropods

Toxicity to terrestrial plants

Toxicity to soil microorganisms

78-16-0 (a)

NOEC (56 d) ≥ 1000 mg/kg

Waiving

Waiving

RA: CAS 68002-79-9 (RL4)

Weight of Evidence

91050-88-3

RA: CAS 78-16-0, CAS 68541-50-4

Waiving

Waiving

RA: CAS 68002-79-9 (RL4)

Weight of Evidence

189120-64-7 (b)

--

--

--

--

11138-60-6

RA: CAS 78-16-0, CAS 68541-50-4

Waiving

Waiving

RA: CAS 68002-79-9 (RL4)

Weight of Evidence

91050-89-4

RA: CAS78-16-0

Waiving

Waiving

RA: CAS 68002-79-9 (RL4)

Weight of Evidence

85566-29-6

RA: CAS 78-16-0, CAS 68541-50-4

Waiving

Waiving

RA: CAS 68002-79-9 (RL4)

Weight of Evidence

(Formerly CAS 85186-89-6)

RA: CAS 78-16-0, CAS 68541-50-4

Waiving

Waiving

RA: CAS 68002-79-9 (RL4)

Weight of Evidence

68002-79-9

RA: CAS 78-16-0, CAS 68541-50-4

Waiving

NOEC (14 d) 300 - 1000 mg/kg dw

Weight of Evidence

EC 931-531-4 (formerly CAS 85005-23-8)

RA: CAS 78-16-0, CAS 68541-50-4

Waiving

Waiving

RA: CAS 68002-79-9 (RL4)

Weight of Evidence

68002-78-8

RA: CAS68541-50-4

Waiving

Waiving

RA: CAS 68002-79-9 (RL4)

Weight of Evidence

EC 931-461-4 (formerly CAS 57675-44-2)

RA: CAS 78-16-0, CAS 68541-50-4

Waiving

Waiving

RA: CAS 68002-79-9 (RL4)

Weight of Evidence

85186-92-1

RA: CAS 78-16-0, CAS 68541-50-4

Waiving

Waiving

RA: CAS 68002-79-9 (RL4)

Weight of Evidence

68541-50-4

NOEC (56 d) ≥ 1000 mg/kg

Waiving

Waiving

RA: CAS 68002-79-9 (RL4)

Weight of Evidence

a) Category members subjected to the REACh Phase-in registration deadline of 31 May 2013 are indicated in bold font

b) Substances that are either already registered under REACh, or not subject to the REACh  Phase-in registration deadline of 31 May 2013, are indicated in normal font

For all category members registered under REACh a full data set for each endpoint is provided. For substances not subject to the current REACh Phase-in registration, lack of data for a given endpoint is indicated by “--“.

NOTE: Not all of polyol esters within the category are discussed in this endpoint summary i.e. only polyol esters of the TMP group. For further information on the complete polyol ester category please refer to category justification (IUCLID Section 13).

 

Experimental data on the toxicity of TMP esters to terrestrial organisms are available for 2-ethyl-2-[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS 78-16-0), Fatty acids, C16-18 (even numbered) and C16-18-unsatd. (even numbered), triesters with trimethylolpropane (CAS 68002-79-9) and 2-ethyl-2-(((1-oxoisooctadecyl)oxy)methyl)-1,3-propanediyl bis (isooctadecanoate) (CAS 68541-50-4).

The long-term toxicity of 2-ethyl-2-[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS 78-16-0) and 2-ethyl-2-(((1-oxoisooctadecyl)oxy)methyl)-1,3-propanediyl bis (isooctadecanoate) (CAS 68541-50-4) to earthworms was tested in two studies according to OECD guideline 222. The studies focused on the effect of the test substances on earthworm survival, growth and reproduction (Eisner, 2013a,b). Mortality or detrimental effects on earthworm growth were not observed and thus a NOEC (28 d) ≥ 1000 mg/kg soil dw based on mortality. The reproduction rate was determined after another 28 days by counting the number of hatched juveniles. A significant difference to the control was not observed and thus a NOEC (56 d) ≥ 1000 mg/kg was determined based on reproduction.

The short-term toxicity of Fatty acids, C16-18 (even numbered) and C16-18-unsatd. (even numbered), triesters with trimethylolpropane (CAS 68002-79-9) was tested according to OECD 208. The study determined no toxicity of the TMP ester on the early seedling growth of the tested plant species (NOEC (14 d) = 300 mg/kg for Lycopersicon esculentum and Raphanus sativus respectively, NOEC (14 d) = 1000 mg/kg for Avena sativa).

Generally the available data on the members of the TMP ester group indicate a low bioavailability and a low toxicity of the substances to terrestrial organisms. Studies on the short-term and chronic toxicity of the TMP ester group to aquatic organism determined no toxicity up to the limit of water solubility. The substances are all readily biodegradable and thus are expected to be largely eliminated in sewage treatment plants by degradation. Furthermore based on the low water solubility (< 1 mg/L) of the TMP ester group members and the high log Koc (3.99 – 14.91) the substances are expected to be mechanically removed in the primary settling tank and fat trap and thus, only limited amounts will get in contact with activated sludge organisms. Consequently a significant release to the environment of the TMP esters via STP effluents is not expected. However, when the substances are released to the environment a rapid degradation is assumed. Since a respiration inhibition of aquatic microorganisms was not observed in the available studies on TMP esters a comparable result is expected for soil microorganisms. This assumption is supported by several studies investigating the degradation of fatty acid esters by soil microorganisms (Hita et al., 1996, Banchio & Gramajo, 1997 and Cecutti et al., 2002).

The characteristics of the TMP ester group (i.e. low water solubility, low vapour pressure and high log Koc) determine the environmental fate of the substances. A distribution to the soil compartment is most probable. The substances have a potential to adsorb to soil particles and thus might be ingested by soil dwelling organisms. However, acute toxicity of the TMP ester group members to terrestrial organisms is not expected based on the data available for short-term aquatic toxicity. When ingested the substances are expected to be rapidly metabolised and excreted. Bioaccumulation is not anticipated. This also supported by the low BCF values (BCF: 0.89 - 39.11 L/kg; Arnot-Gobas) calculated for the TMP ester group members. An uptake of the TMP esters by plant roots is not likely due to the low water solubility and high adsorption potential of the substances.