Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

A detailed justification for grouping of substances is provided in section 5 of IUCLID.

The following table illustrates the read across approach taken within the TMP ester group of the polyol esters category. In order to get a good overview, only the ecotoxicological parameters for the aquatic compartment of the relevant substances used as part of a read across approach for the TMP esters of the category have been listed in the table below. The complete data matrix of all polyol esters for aquatic toxicity is however detailed within the category justification attached in IUCLID section 13 of this dossier. 

Ecotoxicological parameters for the aquatic toxicity of the TMP ester group

ID No.

CAS

Short-term toxicity to fish

Long-term toxicity to fish

Short-term toxicity to aquatic invertebrates

Long-term toxicity to aquatic invertebrates

Toxicity to aquatic algae

Toxicity to microorganisms

14

78-16-0

LC50 (96h) >1000 mg/L

Waiving

RA: CAS

11138-60-6

189120-64-7

RA: CAS 11138-60-6

RA: CAS

11138-60-6

189120-64-7

NOEC (14 d) >= 30.4 mg/L

15

91050-88-3

LL50 (96h) > 1000 mg/L

Waiving

EL50 (48h) > 1000 mg/L

RA: CAS 11138-60-6

EL50 (72h) > 1000 mg/L

RA: CAS 11138-60-6

RA: CAS 57675-44-2

16

97281-24-8

--

--

--

--

--

--

17

189120-64-7

--

--

EL50 (48h) >1000 mg/L (nominal)

EL50 (48h) >0.59 mg/L (measured)

--

EL50 >1000 mg/L (nominal)

EL50 >0.23 mg/L (measured)

--

18

11138-60-6

LL50 (96h) >10000 mg/L

(nom.)

Waiving

EL50 (48h) >100 mg/L

(nom.)

NOELR (15d)≥2570 mg/L (nom.)

EL50 (72h) >100 mg/L

(nom.)

EC50 (3h) >10000 mg/L

(nom.)

19

91050-89-4

LC50 (96h) >10000 mg/L

Waiving

RA: CAS 11138-60-6

RA: CAS 11138-60-6

RA: CAS 11138-60-6

RA: CAS 11138-60-6

20

85566-29-6

RA: CAS 11138-60-6

91050-89-4

85005-23-8

85186-89-6

91050-88-3

Waiving

Waiving

RA: CAS 11138-60-6

91050-88-3

85186-89-6

TESTING PROPOSAL

 

RA: CAS 11138-60-6

RA: CAS 11138-60-6

85186-89-6

91050-88-3

68002-79-9

RA: CAS 11138-60-6

85186-89-6

21

(Formerly 85186-89-6)

LL50 (96h) > 10000 mg/L

(nom.)

Waiving

EL50 (48h) > 100 mg/L

(nom.)

TESTING PROPOSAL

 

RA: CAS 11138-60-6

EL50 (72h) > 100 mg/L

(nom.)

EC50 (3h) > 10000 mg/L

(nom.)

22

403507-18-6

--

--

--

--

--

--

23

68002-79-9

RA: CAS 85005-23-8

Waiving

EC50 (48h) >1000 mg/L

RA: CAS 68002-78-8

EC 931-531-4 (testing proposal)

EL50 (72h) >100 mg/L

RA: CAS 85005-23-8

24

EC# 931-531-4
(formerly 85005-23-8)

LC50 (96h) > 100 mg/L

Waiving

EL50 (96h) > 100 mg/L (RL3)

 

RA: CAS 68002-79-9

TESTING PROPOSAL

 

RA: CAS 68002-78-8

11138-60-6

RA: CAS 68002-79-9

EL50 (16h) > 10000 mg/L (nom.)

25

91050-90-7

--

--

--

--

--

--

26

68002-78-8

LL50 (96h) >102 mg/L

Waiving

EL50 (48h) >106 mg/L

NOELR (21d)≥110 mg/L

EL50 (72h) >110 mg/L

RA: EC 931-461-4

27

EC 931-461-4

(formerly 57675-44-2)

LC50 (96h) >1000 mg/L

RA: CAS 68002 -78 -8

Waiving

EL50 >100 mg/L

RA: CAS 68002-78-8

RA: CAS 68002-78-8

11138-60-6

EC 931-531-4 (testing proposal)

EL50 (72h) >100 mg/L

EC10 (3h) >10000 mg/L

28

85186-92-1

RA: CAS 57675-44-2

68002-78-8

42222-50-4

Waiving

RA: CAS 57675-44-2

68002-78-8

42222-50-4

RA: CAS 68002-78-8

11138-60-6

42222-50-4

EC 931-531-4 (testing proposal)

 

RA: CAS 57675-44-2

68002-78-8

42222-50-4

RA: CAS 57675-44-2

 

29

68541-50-4

LC50 (96h) >48 mg/L

Waiving

EC50 (48h) >7.6 mg/L

RA: CAS 68002-78-8

EC50 >3.7 mg/L

RA: CAS 57675-44-2

 

a) Category members subjected to the REACh Phase-in registration deadline of 31 May 2013 are indicated in bold font

b) Substances that are either already registered under REACh, or not subject to the REACh  Phase-in registration deadline of 31 May 2013, are indicated in normal font

For all category members registered under REACh a full data set for each endpoint is provided. For substances not subject to the current REACh Phase-in registration, lack of data for a given endpoint is indicated by "--".

NOTE: Not all of polyol esters within the category are discussed in this endpoint summary i.e. only polyol esters of the TMP group. For further information on the complete polyol ester category please refer to category justification (IUCLID Section 13).

 

In accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5, grouping and read-across, the polyol esters, which of course includes the polyol TMP group, are not considered to be harmful to aquatic organisms based on the results from short-term studies with fish, aquatic invertebrates and algae and long-term results on toxicity to aquatic invertebrates. Moreover, all polyol TMP esters within the polyol esters category are structurally similar and read-across was performed to the structurally most similar TMP ester group member(s). The available studies cover the variability of the TMP esters group with different alcohol and fatty acid chain lengths. The data gaps within the TMP esters group were filled by interpolation since the group members are characterized by a similar pattern in the ecotoxicological toxicity profile. No trend in toxicity was observed since no effects were recorded up to the limit of water solubility. There is no convincing evidence that any one of the category members might lie out of the overall profile of this category.

Aquatic toxicity

Within the TMP ester group conclusive data on short-term toxicity to freshwater organisms is available for all three trophic levels (algae, aquatic invertebrates and fish). All tests were conducted according to internationally accepted guidelines. The available data is suitable for hazard and risk assessment of the category.

Studies on the acute toxicity to fish are available for almost all TMP esters and thus the data covers the structural variability and different fatty acid chain length within the TMP ester group. Studies testing the short-term toxicity to fish are available for 2-ethyl-2-[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS 78-16-0), Fatty acids, C6-18, triesters with trimethylolpropane (CAS 91050-88-3), Fatty acids, C8-10, triesters with trimethylolpropane (CAS 91050-89-4), Fatty acids, C8-10 (even), C14-18 (even) and C16-18 (even)-unsatd., triesters with trimethylolpropane (CAS 85186-89-6), Fatty acids, C16-18 (even numbered) and C18-unsatd., branched and linear, di- and triesters with trimethylolpropane (EC 931-531-4, formerly 85005-23-8), Fatty acids, C16-18 and C18 unsatd., triesters with trimethylolpropane (CAS 68002-78-8), 2-ethyl-2-(((1-oxoisooctadecyl)oxy)methyl)-1,3-propanediyl bis (isooctadecanoate) (CAS 68541-50-4), Fatty acids, C8-10 (even numbered), di-and triesters with propylidynetrimethanol (CAS 11138-60-6) and Fatty acids, C16-18 even numbered and C18-unsatd. Triesters with propylidynetrimethanol (former CAS 57675-44-2, EC 931-461-4). Acute effects on fish within the limit of water solubility of the TMP ester group members were not reported by any of the studies.

A similar outcome was demonstrated by the tests on acute toxicity to aquatic invertebrates available for the group members Fatty acids, C6-18, triesters with trimethylolpropane (CAS 91050-88-3), Fatty acids, C16-18 and C18 unsatd., triesters with trimethylolpropane (CAS 68002-78-8), Fatty acids, C8-10 (even), C14-18 (even) and C16-18 (even)-unsatd., triesters with trimethylolpropane (CAS 85186-89-6 (formerly), 2-ethyl-2-(((1-oxoisooctadecyl)oxy)methyl)-1,3-propanediyl bis (isooctadecanoate) (CAS 68541-50-4), Fatty acids, C8-10 (even numbered), di-and triesters with propylidynetrimethanol (CAS 11138-60-6), Fatty acids, C16-18 (even numbered) and C16-18-unsatd. (even numbered), triesters with trimethylolpropane (CAS 68002-79-9), Fatty acids, C16-18 even numbered and C18-unsatd. Triesters with propylidynetrimethanol (former CAS 57675-44-2), and Trimethylolpropane ester of heptanoic and octanoic acid (CAS 189120-64-7). Existing data gaps for all remaining category members were filled by read-across to TMP ester group members with the highest structural similarity.

Toxic effects of the TMP ester group members were not observed within the limit of water solubility. A trend in toxicity was not demonstrated by the available studies on short-term toxicity to aquatic organisms. Since the data covers the range of fatty acid chain length and degree of esterification it can be concluded that the demonstrated toxicity profile applies to all TMP esters.

Tests on long-term toxicity are available for two TMP ester group members. In a study on Fatty acids, C8-10 (even numbered), di-and triesters with propylidynetrimethanol (CAS 11138-60-6) with fatty acids of chain length C8 and C10 no chronic effect on Daphnia magna (NOELR (15 d)≥2570 mg/L) were determined. In a second study conducted with the TMP ester Fatty acids, C16-18 and C18 unsatd., triesters with trimethylolpropane (CAS 68002-78-8) with fatty acids of chain length C16-C18 and C18 a NOELR ≥ 0.11 g/L was determined. Generally the two substances reflect the range of fatty acid chain length within the TMP ester group. Therefore a transfer of the results of the two available long-term studies to the other TMP ester group members by read-across is assumed to be suitable.Although chronic toxicity data is available for members within theTMPpolyol estersgroupin accordancewithRegulation (EC) No 1907/2006, Annex IX 9.1 Aquatic toxicity,further long-term studies on aquatic invertebrates were proposed forFatty acids, coco, triester with trimethylolpropane, reaction product of coconut oil fatty acids and trimethylolpropane(CAS 85566-29-6),Fatty acids, C8-10 (even), C14-18 (even) and C16-18 (even)-unsatd., triesters with trimethylolpropane(former CAS 85186-89-6) andFatty acids, C16-18 (even numbered) and C18-unsatd., branched and linear, di- and triesters with trimethylolpropane(former CAS 85005-23-8) to extend the overall dataset and to cover the medium fatty acid chain lengths (C12, C14 and C16) and unsaturated fatty acids (C16:1, C18:1).As soon asthe studies areavailable the hazard and chemical safety assessmentaccording to Annex I of Regulation (EC) No. 1907/2006will be updated.

The toxicity to aquatic algae of the TMP ester group was investigated for 2-ethyl-2-[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS 78-16-0), Fatty acids, C6-18, triesters with trimethylolpropane (CAS 91050-88-3), Trimethylolpropane ester of heptanoic and octanoic acid (CAS 189120-64-7), Fatty acids, C16-18 and C18 unsatd., triesters with trimethylolpropane (CAS 68002-78-8), Fatty acids, C16-18 (even numbered) and C16-18-unsatd. (even numbered), triesters with trimethylolpropane (CAS 68002-79-9), 2-ethyl-2-(((1-oxoisooctadecyl)oxy)methyl)-1,3-propanediyl bis (isooctadecanoate) (CAS 68541-50-4), Fatty acids, C8-10 (even numbered), di-and triesters with propylidynetrimethanol (CAS 11138-60-6) and Fatty acids, C16-18 even numbered and C18-unsatd. Triesters with propylidynetrimethanol (former CAS 57675-44-2). No toxicity was observed up to the limit of water solubility in the available studies. The available studies are covering the variability of fatty acid chain length within the TMP ester group. Thus, the data gaps within the category can be covered by read-across. For each read-across a suitable read-across substance regarding chain length and esterification was chosen.

Data on the toxicity to microorganisms are available for 2-ethyl-2-[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS 78-16-0), Fatty acids, C8-10 (even numbered), di-and triesters with propylidynetrimethanol (CAS 11138-60-6), Fatty acids, C16-18 even numbered and C18-unsatd. Triesters with propylidynetrimethanol (CAS 57675-44-2). Based on the range of fatty acid chain length the studies can be used as read-across for structural similar substances within the TMP ester group. No effects of the substances on respiration or O2 consumption respectively were observed.  

In summary no effects on aquatic organisms were observed by the available studies on TMP esters regarding any of the three trophic levels (fish, daphnia, algae). The available studies determined neither acute nor chronic effects up to the limit of water solubility of TMP esters. The data on the TMP ester group is comprehensive and covers the range of fatty acid chain lengths within the group as well as the degrees of esterification and saturation of the fatty acids. Thus a conclusive outline of the ecotoxicity profile of all TMP ester group members is possible. As demonstrated by the available data all the category members exhibit consistent ecotoxicity profiles and the categorisation is therefore approvable. 

A detailed reference list is provided in the technical dossier (see IUCLID, section 13) and within CSR.