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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1987
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
other: Inhouse method: A-11 devloped by CIBA and is comparable to standard guidline
Deviations:
not specified
GLP compliance:
no
Analytical monitoring:
yes
Details on sampling:
See any other information on materials and methods below.
Vehicle:
yes
Details on test solutions:
300 and 1000 mg/l
Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Details on test organisms:
See any other information on materials and methods below.
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Remarks on exposure duration:
None
Post exposure observation period:
See any other information on materials and methods below.
Hardness:
None
Test temperature:
23 °C
pH:
8.2 to 8.4
Dissolved oxygen:
7.2 - 8.4
Salinity:
None
Conductivity:
None
Nominal and measured concentrations:
300 and 1000 mg/l
Details on test conditions:
See any other information on materials and methods below.
Reference substance (positive control):
not specified
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
462 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
300 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Details on results:
No mortality was found at 300 mg/L while all fish in 1000 mg/L dose group were dead after 4 h.
Validity criteria fulfilled:
not specified
Conclusions:
The LC50 of FAT 40278/A was determined to be 462.39 mg/L.
Executive summary:

The acute fish toxicity test was performed according to a methodology similar to OECD Guideline 203 (CIBA method A-11). Zebrafish (Danio rerio) were used in the experiment setup. Two groups of fish were tested at the 300 and 1000 mg/L concentration. No mortality was found at 300 mg/L while all fish in 1000 mg/L dose group were dead after 4 h exposure. Hence, the LC50 of FAT 40278/A in this fish acute toxicity test was determined to be 462.39 mg/L.

Description of key information

The acute fish toxicity test was performed according to a method similar to OECD Guideline 203 (CIBA method A-11). Zebrafish (Danio rerio) were used in the experiment setup. Two groups of fish were tested at the 300 and 1000 mg/L concentration. No mortality was found at 300 mg/L while all fish in 1000 mg/L dose group were died after 4 h exposire. Hence, the LC50 of FAT 40278/A in this fish acute toxicity test was determined to be 462.39 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
462.39 mg/L

Additional information