Registration Dossier
Registration Dossier
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EC number: 915-277-1 | CAS number: 32052-51-0
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Asthma durch Isocyanate
- Author:
- Baur X
- Year:
- 1 986
- Bibliographic source:
- Allergologie 9, 487-496
Materials and methods
- Endpoint addressed:
- respiratory irritation
Test material
- Reference substance name:
- Trimethylhexa-1,6-diyl diisocyanate
- EC Number:
- 249-151-6
- EC Name:
- Trimethylhexa-1,6-diyl diisocyanate
- Cas Number:
- 28679-16-5
- Molecular formula:
- C11H18N2O2
- IUPAC Name:
- 1,6-Diisocyanatotrimethylhexane
- Details on test material:
- Isocyanates in general (analogy)
Constituent 1
Method
- Type of population:
- occupational
- Examinations:
- In a 4-year epidemological investigation finished in 1983, 247 out of 621 employees included in the study (working mainly in the chemical and
automobile-producing industry) were found to suffer from isocyanate-related diseases (type of compound not specified). In 290 cases, the
respiratory system was affected, in some cases, evidence for hypersensitivity pneumonitis was obtained.
Results and discussion
Applicant's summary and conclusion
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