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EC number: 282-941-9 | CAS number: 84473-86-9
A preliminary study was done
The skin sensitization study of Diantimony Trioxide (1309-64-4)was performed byMagnusson and Kligman methodin20guinea pigs.An additional 10 animals served as the control group. A preliminary study with 8 animals was performed to determine the appropriate dose level for intracutaneous and topical administration
In induction phase,3 pairs of intradermal injections (0.1 ml each); 1) a 1:1 mixture (v/v) of Freund’s complete adjuvant (FCA):0.9 % NaCl. 2) 10 % suspension of diantimony trioxide in water and 3) a 1:1 mixture (v/v) of diantimony trioxide suspension: FCA/ 0.9 % NaCl resulting in a final concentration of diantimony trioxide of 10 % were given in shoulder region. After 6 day,the exposed skin was coated with 0.5 ml sodium lauryl sulphate 10 % in vaseline in order to induce a local irritation then second induction using 50% concentration in water as suspension applied as patch for 48hr in same site as shoulder region.
In challenge phase, after 21 days on left flank region 50% suspension of test material in water was applied as patch for 24hr. After 21hr treated skin cleaned and evaluated for skin sensitization reaction.No indication of skin sensitization was observed.Hence it is considered that Diantimony Trioxide (1309-64-4)was not skin sensitizing in guinea pig by Magnusson and Kligman method
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