Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
January 9th, 2004 to January 23rd, 2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report Date:
2004

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Specific details on test material used for the study:
Test material name (as stated in the report): Cetonal
Batch No.: 9000439021
Expiry date: 28 December, 2004

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
5.5
Temp.:
35 °C
pH:
7
Key result
Type:
log Pow
Partition coefficient:
5.4
Temp.:
35 °C
pH:
7
Details on results:
The determination was performed at 35°C (column temperature), however the values can be considered to represent the values at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log Kow values were determined. Partition coefficients of the test and reference substances are assumed to vary with temperature in the same way.

Applicant's summary and conclusion

Conclusions:
The chromatogram shows two unresolved peaks at retention times 15.0 and 15.6 minutes, corresponding to partition coefficients (log values) of 5.4 and 5.5. Therefore:
Partition coefficient n-octanol/water of Cetonal :
- major peak: Log Pow = 5.4
- minor peak: Log Pow = 5.5
Executive summary:

The Partition Coefficient n-octanol/water of Cetonal was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD guideline No. 117. The chromatogram shows two unresolved peaks at retention times 15.0 and 15.6 minutes, corresponding to partition coefficients (log values) of 5.4 and 5.5. Therefore:

Partition coefficient n-octanol/water of Cetonal :

- major peak: Log Pow = 5.4

- minor peak: Log Pow = 5.5